KSS1/YGR040W Protein Information

Standard Name	Kss1p 1
Systematic Name	Ygr040wp
ORF Classification	Verified
Description	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains (2, 3)
Name Description	Kinase Suppressor of Sst2 mutations 4

Experimental Data
Molecules/cell	5480 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	368
Molecular Weight (Da)	42,692
Isoelectric Point (pI)	5.39

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kss1p (InterPro)
Physical Interactions	There are 199 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012E0D8 \| P14681 MIPS: YGR040W NCBI: 125716 \| 1323037 \| 172185 \| 398365311 \| 45269437 \| 71064029 \| NP_011554.3 GenBank/EMBL/DDBJ: DAA08139.1 \| AY557773 \| DQ115391 \| M26398 \| Z72825
External Classifications	EC: 2.7.11.24 [Mitogen-activated protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MARTITFDIP SQYKLVDLIG EGAYGTVCSA IHKPSGIKVA IKKIQPFSKK 51 LFVTRTIREI KLLRYFHEHE NIISILDKVR PVSIDKLNAV YLVEELMETD 101 LQKVINNQNS GFSTLSDDHV QYFTYQILRA LKSIHSAQVI HRDIKPSNLL 151 LNSNCDLKVC DFGLARCLAS SSDSRETLVG FMTEYVATRW YRAPEIMLTF 201 QEYTTAMDIW SCGCILAEMV SGKPLFPGRD YHHQLWLILE VLGTPSFEDF 251 NQIKSKRAKE YIANLPMRPP LPWETVWSKT DLNPDMIDLL DKMLQFNPDK 301 RISAAEALRH PYLAMYHDPS DEPEYPPLNL DDEFWKLDNK IMRPEEEEEV 351 PIEMLKDMLY DELMKTME*

Amino Acid Sequence (or in FASTA format)

       1  MARTITFDIP SQYKLVDLIG EGAYGTVCSA IHKPSGIKVA IKKIQPFSKK
      51  LFVTRTIREI KLLRYFHEHE NIISILDKVR PVSIDKLNAV YLVEELMETD
     101  LQKVINNQNS GFSTLSDDHV QYFTYQILRA LKSIHSAQVI HRDIKPSNLL
     151  LNSNCDLKVC DFGLARCLAS SSDSRETLVG FMTEYVATRW YRAPEIMLTF
     201  QEYTTAMDIW SCGCILAEMV SGKPLFPGRD YHHQLWLILE VLGTPSFEDF
     251  NQIKSKRAKE YIANLPMRPP LPWETVWSKT DLNPDMIDLL DKMLQFNPDK
     301  RISAAEALRH PYLAMYHDPS DEPEYPPLNL DDEFWKLDNK IMRPEEEEEV
     351  PIEMLKDMLY DELMKTME*

external links for Kss1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Kss1p

1)	Courchesne, W. and Thorner, J. (1989) Personal Communication, Mortimer Map Edition 10
2)	Madhani HD, et al. (1997) MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91(5):673-84
3)	Elion EA, et al. (1991) FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Proc Natl Acad Sci U S A 88(21):9392-6
4)	Courchesne WE, et al. (1989) A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell 58(6):1107-19
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41