NMA2/YGR010W Protein Information

Standard Name	Nma2p 1
Systematic Name	Ygr010wp
ORF Classification	Verified
Description	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Nicotinamide Mononucleotide Adenylyltransferase 1

Experimental Data
Molecules/cell	1430 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	395
Molecular Weight (Da)	44,909
Isoelectric Point (pI)	5.78

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nma2p (InterPro)
Physical Interactions	There are 14 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AF1F \| P53204 MIPS: YGR010W NCBI: 1322971 \| 1723643 \| 6321447 \| NP_011524.1 GenBank/EMBL/DDBJ: DAA08108.1 \| Z72795
External Classifications	EC: 2.7.7.1 [Nicotinamide-nucleotide adenylyltransferase] EC: 2.7.7.18 [Nicotinate-nucleotide adenylyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MDPTKAPDFK PPQPNEELQP PPDPTHTIPK SGPIVPYVLA DYNSSIDAPF 51 NLDIYKTLSS RKKNANSSNR MDHIPLNTSD FQPLSRDVSS EEESEGQSNG 101 IDATLQDVTM TGNLGVLKSQ IADLEEVPHT IVRQARTIED YEFPVHRLTK 151 KLQDPEKLPL IIVACGSFSP ITYLHLRMFE MALDDINEQT RFEVVGGYFS 201 PVSDNYQKRG LAPAYHRVRM CELACERTSS WLMVDAWESL QSSYTRTAKV 251 LDHFNHEINI KRGGIMTVDG EKMGVKIMLL AGGDLIESMG EPHVWADSDL 301 HHILGNYGCL IVERTGSDVR SFLLSHDIMY EHRRNILIIK QLIYNDISST 351 KVRLFIRRGM SVQYLLPNSV IRYIQEYNLY INQSEPVKQV LDSKE*

Amino Acid Sequence (or in FASTA format)

       1  MDPTKAPDFK PPQPNEELQP PPDPTHTIPK SGPIVPYVLA DYNSSIDAPF
      51  NLDIYKTLSS RKKNANSSNR MDHIPLNTSD FQPLSRDVSS EEESEGQSNG
     101  IDATLQDVTM TGNLGVLKSQ IADLEEVPHT IVRQARTIED YEFPVHRLTK
     151  KLQDPEKLPL IIVACGSFSP ITYLHLRMFE MALDDINEQT RFEVVGGYFS
     201  PVSDNYQKRG LAPAYHRVRM CELACERTSS WLMVDAWESL QSSYTRTAKV
     251  LDHFNHEINI KRGGIMTVDG EKMGVKIMLL AGGDLIESMG EPHVWADSDL
     301  HHILGNYGCL IVERTGSDVR SFLLSHDIMY EHRRNILIIK QLIYNDISST
     351  KVRLFIRRGM SVQYLLPNSV IRYIQEYNLY INQSEPVKQV LDSKE*

external links for Nma2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Nma2p

1)	Anderson RM, et al. (2002) Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem 277(21):18881-90
2)	Emanuelli M, et al. (1999) Identification and characterization of YLR328W, the Saccharomyces cerevisiae structural gene encoding NMN adenylyltransferase. Expression and characterization of the recombinant enzyme. FEBS Lett 455(1-2):13-7
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41