STF2/YGR008C Protein Information 
| Standard Name | Stf2p 1 |
|---|---|
| Systematic Name | Ygr008cp |
| ORF Classification | Verified |
| Description | Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6) |
| Name Description | STabilizing Factor 7, 8 |
| Experimental Data | |
|---|---|
| Molecules/cell | 5330 9 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Stf2p (InterPro) |
| Physical Interactions | There are 9 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000004F911 | P16965 MIPS: YGR008C NCBI: 1322967 | 134972 | 1742920 | 218498 | 45270430 | 6321445 | NP_011522.1 | NM_001181137.1 GenBank/EMBL/DDBJ: DAA08106.1 | AY558270 | D00444 | D50644 | Z72793 |
external links for Stf2p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| YGOB | BioPIXIE | MIPS | YeastRC Public Image Repository |
| YOGY | CYC2008 (complexes) | Pfam domains | |
| Complexome | |||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Stf2p
| 1) | Yoshida Y, et al. (1990) Isolation of a gene for a regulatory 15-kDa subunit of mitochondrial F1F0-ATPase and construction of mutant yeast lacking the protein. Eur J Biochem 192(1):49-53 |
| 2) | Dienhart M, et al. (2002) Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J Biol Chem 277(42):39289-95 |
| 3) | Hashimoto T, et al. (1990) Simultaneous bindings of ATPase inhibitor and 9K protein to F1F0-ATPase in the presence of 15K protein in yeast mitochondria. J Biochem 108(1):17-20 |
| 4) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 5) | Lopez-Martinez G, et al. (2012) The STF2p Hydrophilin from Saccharomyces cerevisiae Is Required for Dehydration Stress Tolerance. PLoS One 7(3):e33324 |
| 6) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 7) | Hashimoto T, et al. (1983) Binding properties of an intrinsic ATPase inhibitor and occurrence in yeast mitochondria of a protein factor which stabilizes and facilitates the binding of the inhibitor to F1F0-ATPase. J Biochem 94(3):715-20 |
| 8) | Hashimoto T, et al. (1984) Purification and properties of factors in yeast mitochondria stabilizing the F1F0-ATPase-inhibitor complex. J Biochem 95(1):131-6 |
| 9) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
