ZRT1/YGL255W Protein Information

Standard Name	Zrt1p 1
Systematic Name	Ygl255wp
ORF Classification	Verified
Description	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor (1, 2)
Name Description	Zinc-Regulated Transporter 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	376
Molecular Weight (Da)	41,581
Isoelectric Point (pI)	5.65

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Zrt1p (InterPro)
Transmembrane Domains	There are 8 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013C482 \| P32804 MIPS: YGL255W NCBI: 1150584 \| 1322935 \| 3708 \| 418391 \| 6321182 \| NP_011259.1 GenBank/EMBL/DDBJ: DAA07864.1 \| X67787 \| X94357 \| Z72777
External Classifications	TC: 2.A.5.1

Amino Acid Sequence (or in FASTA format)
1 MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR 51 ISSVFVILFV STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF 101 IHLMDPAYGA IGGTTCVGQT GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW 151 VERKYGLSHD HTHDEIKDTV VRNTAAVSSE NDNENGTANG SHDTKNGVEY 201 YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL GSVGDEFSSL 251 YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG 301 LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK 351 DLRELSFNVI CTLFGAGIMA LIGKWA*

Amino Acid Sequence (or in FASTA format)

       1  MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR
      51  ISSVFVILFV STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF
     101  IHLMDPAYGA IGGTTCVGQT GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW
     151  VERKYGLSHD HTHDEIKDTV VRNTAAVSSE NDNENGTANG SHDTKNGVEY
     201  YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL GSVGDEFSSL
     251  YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG
     301  LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK
     351  DLRELSFNVI CTLFGAGIMA LIGKWA*

external links for Zrt1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	TCDB
	GeneMANIA	YeastRC Structure Prediction (Seattle)

References cited on this page View Complete Literature Guide for Zrt1p

1)	Zhao H and Eide D (1996) The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci U S A 93(6):2454-8
2)	Zhao H and Eide DJ (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52