RTG2/YGL252C Protein Information Help

Standard Name Rtg2p 1
Systematic Name Ygl252cp
ORF Classification Verified
Description Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p (1, 2, 3, 4, 5)
Name Description ReTroGrade regulation 1
Experimental Data
Molecules/cell 3260 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 588
Molecular Weight (Da) 65,572
Isoelectric Point (pI) 7.96

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rtg2p (InterPro)
Physical Interactions There are 54 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052EA5 | P32608
MIPS: YGL252C
NCBI: 1150587 | 1262162 | 1322929 | 1710803 | 51013069 | 6321185 | NP_011262.1
GenBank/EMBL/DDBJ: DAA07867.1 | AY692809 | M97691 | X94357 | Z72774
Amino Acid Sequence (or in FASTA format)
 
       1  MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD
      51  RVGLSLYEVQ YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV
     101  RVIATEATRD AINADEFVNA VYGSTGWKVE ILGQEDETRV GIYGVVSSFN
     151  TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS KPVSLPYGAG TLLRRMRTDD
     201  NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR GGGLRGMGHL
     251  LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS
     301  DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ
     351  DPLLIASRPY APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH
     401  ASYPKELQPT AALHVATRGI IAGCHGLSHR ARALIGIALC SRWGGNIPES
     451  EEKYSQELEQ VVLREGDKAE ALRIVWWTKY IGTIMYVICG VHPGGNIRDN
     501  VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY EVVVRISKDD
     551  LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE*

external links for Rtg2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rtg2p
1) Liao X and Butow RA  (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72(1):61-71
2) Sekito T, et al.  (2000) Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell 11(6):2103-15
3) Komeili A, et al.  (2000) Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol 151(4):863-78
4) Sekito T, et al.  (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell 13(3):795-804
5) Liu Z, et al.  (2003) Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell 12(2):401-11
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41