CSE1/YGL238W Protein Information Help

Standard Name Cse1p
Systematic Name Ygl238wp
Alias Kap109p
ORF Classification Verified
Description Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation (1, 2, 3)
Name Description Chromosome SEgregation 2
Experimental Data
Molecules/cell 23500 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 960
Molecular Weight (Da) 109,355
Isoelectric Point (pI) 4.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cse1p (InterPro)
Physical Interactions There are 39 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F26 | P33307
MIPS: YGL238W
NCBI: 1322903 | 1706161 | 349589 | 58177143 | 6321198 | 67464500 | 67464501 | 793875 | NP_011276.1 | NM_001181104.1
GenBank/EMBL/DDBJ: DAA07880.1 | L14838 | Z49149 | Z72761
Amino Acid Sequence (or in FASTA format)
 
       1  MSDLETVAKF LAESVIASTA KTSERNLRQL ETQDGFGLTL LHVIASTNLP
      51  LSTRLAGALF FKNFIKRKWV DENGNHLLPA NNVELIKKEI VPLMISLPNN
     101  LQVQIGEAIS SIADSDFPDR WPTLLSDLAS RLSNDDMVTN KGVLTVAHSI
     151  FKRWRPLFRS DELFLEIKLV LDVFTAPFLN LLKTVDEQIT ANENNKASLN
     201  ILFDVLLVLI KLYYDFNCQD IPEFFEDNIQ VGMGIFHKYL SYSNPLLEDP
     251  DETEHASVLI KVKSSIQELV QLYTTRYEDV FGPMINEFIQ ITWNLLTSIS
     301  NQPKYDILVS KSLSFLTAVT RIPKYFEIFN NESAMNNITE QIILPNVTLR
     351  EEDVELFEDD PIEYIRRDLE GSDTDTRRRA CTDFLKELKE KNEVLVTNIF
     401  LAHMKGFVDQ YMSDPSKNWK FKDLYIYLFT ALAINGNITN AGVSSTNNLL
     451  NVVDFFTKEI APDLTSNNIP HIILRVDAIK YIYTFRNQLT KAQLIELMPI
     501  LATFLQTDEY VVYTYAAITI EKILTIRESN TSPAFIFHKE DISNSTEILL
     551  KNLIALILKH GSSPEKLAEN EFLMRSIFRV LQTSEDSIQP LFPQLLAQFI
     601  EIVTIMAKNP SNPRFTHYTF ESIGAILNYT QRQNLPLLVD SMMPTFLTVF
     651  SEDIQEFIPY VFQIIAFVVE QSATIPESIK PLAQPLLAPN VWELKGNIPA
     701  VTRLLKSFIK TDSSIFPDLV PVLGIFQRLI ASKAYEVHGF DLLEHIMLLI
     751  DMNRLRPYIK QIAVLLLQRL QNSKTERYVK KLTVFFGLIS NKLGSDFLIH
     801  FIDEVQDGLF QQIWGNFIIT TLPTIGNLLD RKIALIGVLN MVINGQFFQS
     851  KYPTLISSTM NSIIETASSQ SIANLKNDYV DLDNLEEIST FGSHFSKLVS
     901  ISEKPFDPLP EIDVNNGVRL YVAEALNKYN AISGNTFLNT ILPQLTQENQ
     951  VKLNQLLVGN *

external links for Cse1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Cse1p
1) Schroeder AJ, et al.  (1999) Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p. Mol Gen Genet 261(4-5):788-95
2) Xiao Z, et al.  (1993) CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol Cell Biol 13(8):4691-702
3) Hood JK and Silver PA  (1998) Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J Biol Chem 273(52):35142-6
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41