MIG2/YGL209W Protein Information Help

Standard Name Mig2p 1
Systematic Name Ygl209wp
Alias Mlz1p 2
ORF Classification Verified
Description Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Multicopy Inhibitor of GAL gene expression
Experimental Data
Molecules/cell 504 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 382
Molecular Weight (Da) 42,048
Isoelectric Point (pI) 10.5

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mig2p (InterPro)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F0FB | P53035
MIPS: YGL209W
NCBI: 1305495 | 1709032 | 1945303 | 2072740 | 2131076 | 3645896 | 5262964 | 6321229 | NP_011306.1 | NM_001181074.1
GenBank/EMBL/DDBJ: AAB37570.1 | AAC49496.1 | CAA96921.1 | CAA96923.2 | CAA96924.1 | CAA96925.1 | DAA07907.1 | U33754 | U54564 | Z72730 | Z72731 | Z72732
Amino Acid Sequence (or in FASTA format)
       1  MPKKQTNFPV DNENRPFRCD TCHRGFHRLE HKKRHLRTHT GEKPHHCAFP
      51  GCGKSFSRSD ELKRHMRTHT GQSQRRLKKA SVQKQEFLTV SGIPTIASGV
     101  MIHQPIPQVL PANMAINVQA VNGGNIIHAP NAVHPMVIPI MAQPAPIHAS
     151  AASFQPATSP MPISTYTPVP SQSFTSFQSS IGSIQSNSDV SSIFSNMNVR
     201  VNTPRSVPNS PNDGYLHQQH IPQQYQHQTA SPSVAKQQKT FAHSLASALS
     251  TLQKRTPVSA PSTTIESPSS PSDSSHTSAS SSAISLPFSN APSQLAVAKE
     301  LESVYLDSNR YTTKTRRERA KFEIPEEQEE DTNNSSSGSN EEEHESLDHE
     351  SSKSRKKLSG VKLPPVRNLL KQIDVFNGPK RV*                  

external links for Mig2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
YGOB CYC2008 (complexes) MIPS YPL+
YOGY Complexome Pfam domains YeastGFP

GeneMANIA YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mig2p
1) Lutfiyya LL and Johnston M  (1996) Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol Cell Biol 16(9):4790-7
2) Kail M, et al.  (1996) Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Yeast 12(8):799-807
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Fernandez-Cid A, et al.  (2012) Glucose levels regulate the nucleo-mitochondrial distribution of Mig2. Mitochondrion 12(3):370-80
5) Karunanithi S and Cullen PJ  (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41