MIG2/YGL209W Protein Information

Standard Name	Mig2p 1
Systematic Name	Ygl209wp
Alias	Mlz1p 2
ORF Classification	Verified
Description	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description	Multicopy Inhibitor of GAL gene expression

Experimental Data
Molecules/cell	504 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	382
Molecular Weight (Da)	42,048
Isoelectric Point (pI)	10.5

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mig2p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F0FB \| P53035 MIPS: YGL209W NCBI: 1305495 \| 1709032 \| 1945303 \| 2072740 \| 2131076 \| 3645896 \| 5262964 \| 6321229 \| NP_011306.1 GenBank/EMBL/DDBJ: DAA07907.1 \| U33754 \| U54564 \| Z72730 \| Z72731 \| Z72732

Amino Acid Sequence (or in FASTA format)
1 MPKKQTNFPV DNENRPFRCD TCHRGFHRLE HKKRHLRTHT GEKPHHCAFP 51 GCGKSFSRSD ELKRHMRTHT GQSQRRLKKA SVQKQEFLTV SGIPTIASGV 101 MIHQPIPQVL PANMAINVQA VNGGNIIHAP NAVHPMVIPI MAQPAPIHAS 151 AASFQPATSP MPISTYTPVP SQSFTSFQSS IGSIQSNSDV SSIFSNMNVR 201 VNTPRSVPNS PNDGYLHQQH IPQQYQHQTA SPSVAKQQKT FAHSLASALS 251 TLQKRTPVSA PSTTIESPSS PSDSSHTSAS SSAISLPFSN APSQLAVAKE 301 LESVYLDSNR YTTKTRRERA KFEIPEEQEE DTNNSSSGSN EEEHESLDHE 351 SSKSRKKLSG VKLPPVRNLL KQIDVFNGPK RV*

Amino Acid Sequence (or in FASTA format)

       1  MPKKQTNFPV DNENRPFRCD TCHRGFHRLE HKKRHLRTHT GEKPHHCAFP
      51  GCGKSFSRSD ELKRHMRTHT GQSQRRLKKA SVQKQEFLTV SGIPTIASGV
     101  MIHQPIPQVL PANMAINVQA VNGGNIIHAP NAVHPMVIPI MAQPAPIHAS
     151  AASFQPATSP MPISTYTPVP SQSFTSFQSS IGSIQSNSDV SSIFSNMNVR
     201  VNTPRSVPNS PNDGYLHQQH IPQQYQHQTA SPSVAKQQKT FAHSLASALS
     251  TLQKRTPVSA PSTTIESPSS PSDSSHTSAS SSAISLPFSN APSQLAVAKE
     301  LESVYLDSNR YTTKTRRERA KFEIPEEQEE DTNNSSSGSN EEEHESLDHE
     351  SSKSRKKLSG VKLPPVRNLL KQIDVFNGPK RV*

external links for Mig2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mig2p

1)	Lutfiyya LL and Johnston M (1996) Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol Cell Biol 16(9):4790-7
2)	Kail M, et al. (1996) Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Yeast 12(8):799-807
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Fernandez-Cid A, et al. (2012) Glucose levels regulate the nucleo-mitochondrial distribution of Mig2. Mitochondrion 12(3):370-80
5)	Karunanithi S and Cullen PJ (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41