HOS2/YGL194C Protein Information

Standard Name	Hos2p
Systematic Name	Ygl194cp
Alias	Rtl1p
ORF Classification	Verified
Description	Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS (1, 2, 3, 4)
Name Description	Hda One Similar 5

Experimental Data
Molecules/cell	4890 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	452
Molecular Weight (Da)	51,454
Isoelectric Point (pI)	4.88

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hos2p (InterPro)
Physical Interactions	There are 38 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F47 \| P53096 MIPS: YGL194C NCBI: 1177634 \| 1322819 \| 1723948 \| 6321244 \| NP_011321.1 GenBank/EMBL/DDBJ: DAA07921.1 \| X91837 \| Z72716
External Classifications	EC: 3.5.1.98 [Histone deacetylase]

Amino Acid Sequence (or in FASTA format)
1 MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF 51 RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN 101 ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA 151 INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG 201 VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG 251 IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH 301 GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED 351 IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV 401 RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA 451 FS*

Amino Acid Sequence (or in FASTA format)

       1  MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF
      51  RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN
     101  ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA
     151  INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG
     201  VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG
     251  IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH
     301  GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED
     351  IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV
     401  RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA
     451  FS*

external links for Hos2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Hos2p

1)	Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004
2)	Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
3)	Wang A, et al. (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41