MPT5/YGL178W Protein Information 
| Standard Name | Mpt5p 1 |
|---|---|
| Systematic Name | Ygl178wp |
| Alias | Htr1p , Puf5p , Uth4p |
| ORF Classification | Verified |
| Description | mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity (1, 2, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Multicopy suppressor of Pop Two 10 |
| Experimental Data | |
|---|---|
| Molecules/cell | 1240 11 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Mpt5p (InterPro) |
| Physical Interactions | There are 36 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000168329 | P39016 MIPS: YGL178W NCBI: 116242633 | 1209471 | 1322786 | 450490 | 469512 | 6321260 | 730058 | 794145 | NP_011337.1 | NM_001181043.1 GenBank/EMBL/DDBJ: DAA07936.1 | D25541 | D26184 | X83690 | Z72700 |
external links for Mpt5p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| YGOB | BioPIXIE | MIPS | YeastGFP |
| YOGY | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Complexome | YeastRC Structure Prediction (Seattle) | ||
| DIP | |||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Mpt5p
| 1) | Chen T and Kurjan J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39 |
| 2) | Kennedy BK, et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91 |
| 3) | Tadauchi T, et al. (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61 |
| 4) | Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 |
| 5) | Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79 |
| 6) | Goldstrohm AC, et al. (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13(6):533-9 |
| 7) | Stewart MS, et al. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell 6(2):262-70 |
| 8) | Traven A, et al. (2010) The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS One 5(5):e10651 |
| 9) | Cridge AG, et al. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res 38(22):8039-50 |
| 10) | Hata H, et al. (1998) Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. Genetics 148(2):571-9 |
| 11) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
