ARI1/YGL157W Protein Information

Standard Name	Ari1p 1
Systematic Name	Ygl157wp
ORF Classification	Verified
Description	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily (2, 3)
Name Description	Aldehyde Reductase Intermediate, subclass of SDR 1

Experimental Data
Molecules/cell	2950 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	347
Molecular Weight (Da)	38,083
Isoelectric Point (pI)	5.75

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ari1p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B107 \| P53111 MIPS: YGL157W NCBI: 1322748 \| 1723933 \| 398364383 \| NP_011358.3 \| NM_001181022.3 GenBank/EMBL/DDBJ: DAA07955.1 \| Z48618 \| Z72679
External Classifications	EC: 1.1.1.- [Oxidoreductases With NAD+ or NADP+ as acceptor]

Amino Acid Sequence (or in FASTA format)
1 MTTDTTVFVS GATGFIALHI MNDLLKAGYT VIGSGRSQEK NDGLLKKFNN 51 NPKLSMEIVE DIAAPNAFDE VFKKHGKEIK IVLHTASPFH FETTNFEKDL 101 LTPAVNGTKS ILEAIKKYAA DTVEKVIVTS STAALVTPTD MNKGDLVITE 151 ESWNKDTWDS CQANAVAAYC GSKKFAEKTA WEFLKENKSS VKFTLSTINP 201 GFVFGPQMFA DSLKHGINTS SGIVSELIHS KVGGEFYNYC GPFIDVRDVS 251 KAHLVAIEKP ECTGQRLVLS EGLFCCQEIV DILNEEFPQL KGKIATGEPA 301 TGPSFLEKNS CKFDNSKTKK LLGFQFYNLK DCIVDTAAQM LEVQNEA*

Amino Acid Sequence (or in FASTA format)

       1  MTTDTTVFVS GATGFIALHI MNDLLKAGYT VIGSGRSQEK NDGLLKKFNN
      51  NPKLSMEIVE DIAAPNAFDE VFKKHGKEIK IVLHTASPFH FETTNFEKDL
     101  LTPAVNGTKS ILEAIKKYAA DTVEKVIVTS STAALVTPTD MNKGDLVITE
     151  ESWNKDTWDS CQANAVAAYC GSKKFAEKTA WEFLKENKSS VKFTLSTINP
     201  GFVFGPQMFA DSLKHGINTS SGIVSELIHS KVGGEFYNYC GPFIDVRDVS
     251  KAHLVAIEKP ECTGQRLVLS EGLFCCQEIV DILNEEFPQL KGKIATGEPA
     301  TGPSFLEKNS CKFDNSKTKK LLGFQFYNLK DCIVDTAAQM LEVQNEA*

external links for Ari1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ari1p

1)	Bowman MJ, et al. (2010) Stereochemistry of furfural reduction by a Saccharomyces cerevisiae aldehyde reductase that contributes to in situ furfural detoxification. Appl Environ Microbiol 76(15):4926-32
2)	Katz M, et al. (2003) Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae. Biotechnol Bioeng 84(5):573-82
3)	Liu ZL and Moon J (2009) A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Gene 446(1):1-10
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41