INO80/YGL150C Protein Information Help

Standard Name Ino80p 1
Systematic Name Ygl150cp
ORF Classification Verified
Description ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription (1, 2, 3, 4, 5)
Name Description INOsitol requiring
Experimental Data
Molecules/cell 6280 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,489
Molecular Weight (Da) 171,454
Isoelectric Point (pI) 5.54

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ino80p (InterPro)
Physical Interactions There are 134 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053052 | P53115
MIPS: YGL150C
NCBI: 1322734 | 1498234 | 1723929 | 6321289 | 728695 | NP_011365.1
GenBank/EMBL/DDBJ: DAA07961.1 | X99960 | Z48618 | Z72672
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.12 [DNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSLAVLLNKE DKDISDFSKT TAGKSAKKNS RERVADVAPT RVLDKKQAYL
      51  SQLNSEFNRI KRRDSIEQLY QDWKFINLQE FELISEWNQQ SKDWQFDNTN
     101  DSQDLHFKKL YRDMSMINKE WAEYQSFKNA NLSDIINEKD ADEDEEDDED
     151  ELEDGEEDME EDEASTGRHT NGKSMRGNGI QKSRKKDAAA AAAIGKAIKD
     201  DQTHADTVVT VNGDENEDGN NGEDEDNDND NENNNDNDND NENENDNDSD
     251  NDDEEENGEE DEEEEEIEDL DEEDFAAFEE QDDNDDEDFN PDVEKRRKRS
     301  SSSSSSTKLS MNSLSLITSK KINKNITINS DRPKIVRELI KMCNKNKHQK
     351  IKKRRFTNCI VTDYNPIDSK LNIKITLKQY HVKRLKKLIN DAKREREREE
     401  ALKNNVGLDG NDLDNDEDGS ESHKRRKLNN NTANGADDAN KRKFNTRHGL
     451  PTYGMKMNAK EARAIQRHYD NTYTTIWKDM ARKDSTKMSR LVQQIQSIRS
     501  TNFRKTSSLC AREAKKWQSK NFKQIKDFQT RARRGIREMS NFWKKNEREE
     551  RDLKKKIEKE AMEQAKKEEE EKESKRQAKK LNFLLTQTEL YSHFIGRKIK
     601  TNELEGNNVS SNDSESQKNI DISALAPNKN DFHAIDFDNE NDEQLRLRAA
     651  ENASNALAET RAKAKQFDDH ANAHEEEEEE DELNFQNPTS LGEITIEQPK
     701  ILACTLKEYQ LKGLNWLANL YDQGINGILA DEMGLGKTVQ SISVLAHLAE
     751  NHNIWGPFLV VTPASTLHNW VNEISKFLPQ FKILPYWGNA NDRKVLRKFW
     801  DRKNLRYNKN APFHVMVTSY QMVVTDANYL QKMKWQYMIL DEAQAIKSSQ
     851  SSRWKNLLSF HCRNRLLLTG TPIQNSMQEL WALLHFIMPS LFDSHDEFNE
     901  WFSKDIESHA EANTKLNQQQ LRRLHMILKP FMLRRVKKNV QSELGDKIEI
     951  DVLCDLTQRQ AKLYQVLKSQ ISTNYDAIEN AATNDSTSNS ASNSGSDQNL
    1001  INAVMQFRKV CNHPDLFERA DVDSPFSFTT FGKTTSMLTA SVANNNSSVI
    1051  SNSNMNLSSM SSNNISNGKF TDLIYSSRNP IKYSLPRLIY EDLILPNYNN
    1101  DVDIANKLKN VKFNIFNPST NYELCLFLSK LTGEPSLNEF FRVSTTPLLK
    1151  RVIERTNGPK NTDSLSFKTI TQELLEVTRN APSEGVMASL LNVEKHAYER
    1201  EYLNCIQRGY HPNVSAPPVT IEVLGSSHVT NSINNELFDP LISQALSDIP
    1251  AITQYNMHVK KGIPVEDFPK TGLFPEPLNK NFSSNISMPS MDRFITESAK
    1301  LRKLDELLVK LKSEGHRVLI YFQMTKMMDL MEEYLTYRQY NHIRLDGSSK
    1351  LEDRRDLVHD WQTNPEIFVF LLSTRAGGLG INLTAADTVI FYDSDWNPTI
    1401  DSQAMDRAHR LGQTRQVTVY RLLVRGTIEE RMRDRAKQKE QVQQVVMEGK
    1451  TQEKNIKTIE VGENDSEVTR EGSKSISQDG IKEAASALA*

external links for Ino80p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ino80p
1) Ebbert R, et al.  (1999) The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular-weight protein complex. Mol Microbiol 32(4):741-51
2) Shen X, et al.  (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4
3) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
4) Klopf E, et al.  (2009) Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol 29(18):4994-5007
5) Udugama M, et al.  (2011) The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor. Mol Cell Biol 31(4):662-73
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41