MRM2/YGL136C Protein Information

Standard Name	Mrm2p
Systematic Name	Ygl136cp
ORF Classification	Verified
Description	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ (1, 2)
Name Description	Mitochondrial rRNA Methyl transferase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	320
Molecular Weight (Da)	37,423
Isoelectric Point (pI)	9.67

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mrm2p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B0FE \| P53123 MIPS: YGL136C NCBI: 1246842 \| 1322708 \| 1723920 \| 45270890 \| 6321302 \| NP_011379.1 GenBank/EMBL/DDBJ: DAA07974.1 \| AY558500 \| X92670 \| Z72658
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases] EC: 2.1.1.168 [21S rRNA (uridine(2791)-2'-O)-methyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MILVYNRIRS IISSSLGRIH VRYNSNSQNR WLNRQLKDPY TKEAKVQNLR 51 SRAAFKLMQI DDKYRLFSKN RTDQRILDLG YAPGAWSQVA RQRSSPNSMI 101 LGVDILPCEP PHGVNSIQAN ILAKRTHDLI RLFFSKHFQL NRHDDLHKDH 151 GYFQNMLEEE LTHVKDTELY REIFTSDDIY ETPNTNSTLI EREKFPVDVI 201 ISDMYEPWPQ TTGFWNNITN QAYFRMANTS GVSIRDHYQS IDLCDAALVT 251 AIDLLRPLGS FVCKLYTGEE ENLFKKRMQA VFTNVHKFKP DASRDESKET 301 YYIGLKKKRN VDKLDVFSNS *

Amino Acid Sequence (or in FASTA format)

       1  MILVYNRIRS IISSSLGRIH VRYNSNSQNR WLNRQLKDPY TKEAKVQNLR
      51  SRAAFKLMQI DDKYRLFSKN RTDQRILDLG YAPGAWSQVA RQRSSPNSMI
     101  LGVDILPCEP PHGVNSIQAN ILAKRTHDLI RLFFSKHFQL NRHDDLHKDH
     151  GYFQNMLEEE LTHVKDTELY REIFTSDDIY ETPNTNSTLI EREKFPVDVI
     201  ISDMYEPWPQ TTGFWNNITN QAYFRMANTS GVSIRDHYQS IDLCDAALVT
     251  AIDLLRPLGS FVCKLYTGEE ENLFKKRMQA VFTNVHKFKP DASRDESKET
     301  YYIGLKKKRN VDKLDVFSNS *

external links for Mrm2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Mrm2p

1)	Pintard L, et al. (2002) MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. EMBO J 21(5):1139-47
2)	Bonnerot C, et al. (2003) Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Mol Cell 12(5):1309-15