SEH1/YGL100W Protein Information

Standard Name	Seh1p
Systematic Name	Ygl100wp
ORF Classification	Verified
Description	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 (1, 2, 3, 4, 5, 6, 7)
Name Description	SEc13 Homolog 3

Experimental Data
Molecules/cell	952 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	349
Molecular Weight (Da)	39,122
Isoelectric Point (pI)	5.32

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Seh1p (InterPro)
Physical Interactions	There are 127 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F8A \| P53011 MIPS: YGL100W NCBI: 1177640 \| 1322639 \| 1711370 \| 212375065 \| 212375067 \| 226438261 \| 226438262 \| 226438265 \| 226438266 \| 226438269 \| 226438270 \| 226438273 \| 226438274 \| 226438277 \| 226438278 \| 226438281 \| 226438282 \| 226438285 \| 226438286 \| 45270884 \| 6321338 \| NP_011415.1 GenBank/EMBL/DDBJ: DAA08006.1 \| AY558497 \| X90994 \| Z72622

Amino Acid Sequence (or in FASTA format)
1 MQPFDSGHDD LVHDVVYDFY GRHVATCSSD QHIKVFKLDK DTSNWELSDS 51 WRAHDSSIVA IDWASPEYGR IIASASYDKT VKLWEEDPDQ EECSGRRWNK 101 LCTLNDSKGS LYSVKFAPAH LGLKLACLGN DGILRLYDAL EPSDLRSWTL 151 TSEMKVLSIP PANHLQSDFC LSWCPSRFSP EKLAVSALEQ AIIYQRGKDG 201 KLHVAAKLPG HKSLIRSISW APSIGRWYQL IATGCKDGRI RIFKITEKLS 251 PLASEESLTN SNMFDNSADV DMDAQGRSDS NTEEKAELQS NLQVELLSEH 301 DDHNGEVWSV SWNLTGTILS SAGDDGKVRL WKATYSNEFK CMSVITAQQ*

Amino Acid Sequence (or in FASTA format)

       1  MQPFDSGHDD LVHDVVYDFY GRHVATCSSD QHIKVFKLDK DTSNWELSDS
      51  WRAHDSSIVA IDWASPEYGR IIASASYDKT VKLWEEDPDQ EECSGRRWNK
     101  LCTLNDSKGS LYSVKFAPAH LGLKLACLGN DGILRLYDAL EPSDLRSWTL
     151  TSEMKVLSIP PANHLQSDFC LSWCPSRFSP EKLAVSALEQ AIIYQRGKDG
     201  KLHVAAKLPG HKSLIRSISW APSIGRWYQL IATGCKDGRI RIFKITEKLS
     251  PLASEESLTN SNMFDNSADV DMDAQGRSDS NTEEKAELQS NLQVELLSEH
     301  DDHNGEVWSV SWNLTGTILS SAGDDGKVRL WKATYSNEFK CMSVITAQQ*

external links for Seh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Seh1p

1)	Lillo JA, et al. (2000) Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Yeast 16(4):365-75
2)	Siniossoglou S, et al. (2000) Structure and assembly of the Nup84p complex. J Cell Biol 149(1):41-54
3)	Siniossoglou S, et al. (1996) A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84(2):265-75
4)	Lutzmann M, et al. (2002) Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J 21(3):387-97
5)	Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12
6)	Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 10(6):M110.006478
7)	Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41