MMS2/YGL087C Protein Information Help

Standard Name Mms2p 1
Systematic Name Ygl087cp
ORF Classification Verified
Description Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description Methyl MethaneSulfonate sensitivity
Experimental Data
Molecules/cell 2760 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 137
Molecular Weight (Da) 15,545
Isoelectric Point (pI) 6.76

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mms2p (InterPro)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F28C | P53152
MIPS: YGL087C
NCBI: 1322613 | 14719687 | 1723880 | 2967521 | 6321351 | NP_011428.1 | NM_001180952.1
GenBank/EMBL/DDBJ: AAC24241.1 | CAA96792.1 | DAA08018.1 | U66724 | Z72609
Amino Acid Sequence (or in FASTA format)
       1  MSKVPRNFRL LEELEKGEKG FGPESCSYGL ADSDDITMTK WNGTILGPPH
      51  SNHENRIYSL SIDCGPNYPD SPPKVTFISK INLPCVNPTT GEVQTDFHTL
     101  RDWKRAYTME TLLLDLRKEM ATPANKKLRQ PKEGETF*             

external links for Mms2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
Candida (CGD) Complexome Pfam domains YeastGFP
YGOB DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository
YOGY GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Mms2p
1) Broomfield S, et al.  (1998) MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway. Proc Natl Acad Sci U S A 95(10):5678-83
2) Ulrich HD and Jentsch S  (2000) Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J 19(13):3388-97
3) Hofmann RM and Pickart CM  (1999) Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96(5):645-53
4) Ulrich HD  (2003) Protein-protein interactions within an E2-RING finger complex. Implications for ubiquitin-dependent DNA damage repair. J Biol Chem 278(9):7051-8
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41