HSF1/YGL073W Protein Information Help

Standard Name Hsf1p 1
Systematic Name Ygl073wp
Alias Exa3p , Mas3p
ORF Classification Verified
Description Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated (2, 3, 4, 5)
Name Description Heat Shock transcription Factor 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 833
Molecular Weight (Da) 93,281
Isoelectric Point (pI) 5.14

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hsf1p (InterPro)
Physical Interactions There are 28 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012CCF6 | P10961
MIPS: YGL073W
NCBI: 123687 | 1322586 | 171708 | 171710 | 398364623 | NP_011442.3
GenBank/EMBL/DDBJ: DAA08031.1 | J03139 | M22040 | Z72596
Amino Acid Sequence (or in FASTA format)
 
       1  MNNAANTGTT NESNVSDAPR IEPLPSLNDD DIEKILQPND IFTTDRTDAS
      51  TTSSTAIEDI INPSLDPQSA ASPVPSSSFF HDSRKPSTST HLVRRGTPLG
     101  IYQTNLYGHN SRENTNPNST LLSSKLLAHP PVPYGQNPDL LQHAVYRAQP
     151  SSGTTNAQPR QTTRRYQSHK SRPAFVNKLW SMLNDDSNTK LIQWAEDGKS
     201  FIVTNREEFV HQILPKYFKH SNFASFVRQL NMYGWHKVQD VKSGSIQSSS
     251  DDKWQFENEN FIRGREDLLE KIIRQKGSSN NHNSPSGNGN PANGSNIPLD
     301  NAAGSNNSNN NISSSNSFFN NGHLLQGKTL RLMNEANLGD KNDVTAILGE
     351  LEQIKYNQIA ISKDLLRINK DNELLWQENM MARERHRTQQ QALEKMFRFL
     401  TSIVPHLDPK MIMDGLGDPK VNNEKLNSAN NIGLNRDNTG TIDELKSNDS
     451  FINDDRNSFT NATTNARNNM SPNNDDNSID TASTNTTNRK KNIDENIKNN
     501  NDIINDIIFN TNLANNLSNY NSNNNAGSPI RPYKQRYLLK NRANSSTSSE
     551  NPSLTPFDIE SNNDRKISEI PFDDEEEEET DFRPFTSRDP NNQTSENTFD
     601  PNRFTMLSDD DLKKDSHTND NKHNESDLFW DNVHRNIDEQ DARLQNLENM
     651  VHILSPGYPN KSFNNKTSST NTNSNMESAV NVNSPGFNLQ DYLTGESNSP
     701  NSVHSVPSNG SGSTPLPMPN DNDTEHASTS VNQGENGSGL TPFLTVDDHT
     751  LNDNNTSEGS TRVSPDIKFS ATENTKVSDN LPSFNDHSYS TQADTAPENA
     801  KKRFVEEIPE PAIVEIQDPT EYNDHRLPKR AKK*

external links for Hsf1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hsf1p
1) Wiederrecht G, et al.  (1988) Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54(6):841-53
2) Bulman AL, et al.  (2001) The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains. J Biol Chem 276(43):40254-62
3) Bonner JJ, et al.  (2000) Structural analysis of yeast HSF by site-specific crosslinking. J Mol Biol 302(3):581-92
4) Hoj A and Jakobsen BK  (1994) A short element required for turning off heat shock transcription factor: evidence that phosphorylation enhances deactivation. EMBO J 13(11):2617-24
5) Yamamoto A, et al.  (2005) Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. J Biol Chem 280(12):11911-9
6) Bonner JJ, et al.  (1992) Temperature-dependent regulation of a heterologous transcriptional activation domain fused to yeast heat shock transcription factor. Mol Cell Biol 12(3):1021-30