MRH4/YGL064C Protein Information

Standard Name	Mrh4p 1
Systematic Name	Ygl064cp
ORF Classification	Verified
Description	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function (1)
Name Description	Mitochondrial RNA Helicase 1

Experimental Data
Molecules/cell	736 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	561
Molecular Weight (Da)	63,057
Isoelectric Point (pI)	10.75

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mrh4p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053180 \| P53166 MIPS: YGL064C NCBI: 1322570 \| 1723845 \| 6321374 \| NP_011451.1 GenBank/EMBL/DDBJ: DAA08038.1 \| Z72586
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides] EC: 3.6.4.13 [RNA helicase]

Amino Acid Sequence (or in FASTA format)
1 MSLFFKPVIS PQWSFPVLLK IGVRSYAGGP RTKHKGNSPL ASVPTGSSNK 51 NRKQKAKGKK GNKKNDPDQA FNFGEYGGLK KDVEMNMDST NKLIQKISNF 101 DQLLILPPVR DAVKEIISKE SLKLQDSRKK TSENIIPSPI QTVAIKRISK 151 NLMDPKLQIH AIAAETGSGK TMAYLIPLID YLKRQELETP ELWETLRKNV 201 LIRSIILVPT HELVDQVYET VSKTKTLLGL NSFKWDKATS YRDLLENIKN 251 RIDILVTTPG KLLNLFSIRM ITRPDKVLSK VGFVVLDEAD TLLDRSWLEE 301 THSAIKRIPN INHLIFCSAT IPQEFNKTMQ RLFPTVVPIM TPRLHKLPFA 351 LDFKVINSAL SPFKGSKIKA LAQTLYAISN DDTEPGFEKR CIIFVNEKKN 401 VPEIVNLLNK KFGHNAIGLT GEDTFEERSE KIMPFLSPPR PLSEVVAQST 451 SPPTSLKKFE IPDSNIVIGK LKNTNSNGTA PSNKSLHVLV TTDLMARGLN 501 FKGVRNVVLY DVPKTSIDLI HRVGRTARMK QGGRVFMLTD SKTKSWAKAL 551 PKIIKKHQRL S*

Amino Acid Sequence (or in FASTA format)

       1  MSLFFKPVIS PQWSFPVLLK IGVRSYAGGP RTKHKGNSPL ASVPTGSSNK
      51  NRKQKAKGKK GNKKNDPDQA FNFGEYGGLK KDVEMNMDST NKLIQKISNF
     101  DQLLILPPVR DAVKEIISKE SLKLQDSRKK TSENIIPSPI QTVAIKRISK
     151  NLMDPKLQIH AIAAETGSGK TMAYLIPLID YLKRQELETP ELWETLRKNV
     201  LIRSIILVPT HELVDQVYET VSKTKTLLGL NSFKWDKATS YRDLLENIKN
     251  RIDILVTTPG KLLNLFSIRM ITRPDKVLSK VGFVVLDEAD TLLDRSWLEE
     301  THSAIKRIPN INHLIFCSAT IPQEFNKTMQ RLFPTVVPIM TPRLHKLPFA
     351  LDFKVINSAL SPFKGSKIKA LAQTLYAISN DDTEPGFEKR CIIFVNEKKN
     401  VPEIVNLLNK KFGHNAIGLT GEDTFEERSE KIMPFLSPPR PLSEVVAQST
     451  SPPTSLKKFE IPDSNIVIGK LKNTNSNGTA PSNKSLHVLV TTDLMARGLN
     501  FKGVRNVVLY DVPKTSIDLI HRVGRTARMK QGGRVFMLTD SKTKSWAKAL
     551  PKIIKKHQRL S*

external links for Mrh4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mrh4p

1)	Schmidt U, et al. (2002) A novel mitochondrial DEAD box protein (Mrh4) required for maintenance of mtDNA in Saccharomyces cerevisiae. FEMS Yeast Res 2(3):267-76
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41