TIF4632/YGL049C Protein Information Help

Standard Name Tif4632p 1
Systematic Name Ygl049cp
ORF Classification Verified
Description Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Translation Initiation Factor 1
Gene Product eIF4G2 5
Experimental Data
Molecules/cell 3390 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 914
Molecular Weight (Da) 103,898
Isoelectric Point (pI) 7.69

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tif4632p (InterPro)
Physical Interactions There are 104 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052DEA | P39936
MIPS: YGL049C
NCBI: 1322541 | 295677 | 6321389 | 729818 | NP_011466.1
GenBank/EMBL/DDBJ: DAA08052.1 | L16924 | Z72571
Amino Acid Sequence (or in FASTA format)
 
       1  MTDQRGPPPP HPQQANGYKK FPPHDNQYSG ANNSQPNNHY NENLYSAREP
      51  HNNKQYQSKN GKYGTNKYNN RNNSQGNAQY YNNRFNNGYR LNNNDYNPAM
     101  LPGMQWPANY YAPQMYYIPQ QMVPVASPPY THQPLNTNPE PPSTPKTTKI
     151  EITTKTGERL NLKKFHEEKK ASKGEEKNDG VEQKSKSGTP FEKEATPVLP
     201  ANEAVKDTLT ETSNEKSTSE AENTKRLFLE QVRLRKAAME RKKNGLISET
     251  EKKQETSNHD NTDTTKPNSV IESEPIKEAP KPTGEANEVV IDGKSGASVK
     301  TPQHVTGSVT KSVTFNEPEN ESSSQDVDEL VKDDDTTEIS DTTGGKTVNK
     351  SDDETINSVI TTEENTVKET EPSTSDIEMP TVSQLLETLG KAQPISDIYE
     401  FAYPENVERP DIKYKKPSVK YTYGPTFLLQ FKDKLKFRPD PAWVEAVSSK
     451  IVIPPHIARN KPKDSGRFGG DFRSPSMRGM DHTSSSRVSS KRRSKRMGDD
     501  RRSNRGYTSR KDREKAAEKA EEQAPKEEIA PLVPSANRWI PKSRVKKTEK
     551  KLAPDGKTEL FDKEEVERKM KSLLNKLTLE MFDSISSEIL DIANQSKWED
     601  DGETLKIVIE QIFHKACDEP HWSSMYAQLC GKVVKDLDPN IKDKENEGKN
     651  GPKLVLHYLV ARCHEEFEKG WADKLPAGED GNPLEPEMMS DEYYIAAAAK
     701  RRGLGLVRFI GYLYCLNLLT GKMMFECFRR LMKDLNNDPS EETLESVIEL
     751  LNTVGEQFEH DKFVTPQATL EGSVLLDNLF MLLQHIIDGG TISNRIKFKL
     801  IDVKELREIK HWNSAKKDAG PKTIQQIHQE EEQLRQKKNS QRSNSRFNNH
     851  NQSNSNRYSS NRRNMQNTQR DSFASTKTGS FRNNQRNARK VEEVSQAPRA
     901  NMFDALMNND GDSD*

external links for Tif4632p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Tif4632p
1) Goyer C, et al.  (1993) TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol 13(8):4860-74
2) Tarun SZ Jr, et al.  (1997) Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Proc Natl Acad Sci U S A 94(17):9046-51
3) Dominguez D, et al.  (1999) Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae. J Biol Chem 274(38):26720-6
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Neff CL and Sachs AB  (1999) Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol 19(8):5557-64
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41