MIG1/YGL035C Protein Information Help

Standard Name Mig1p 1
Systematic Name Ygl035cp
Alias Cat4p , Ssn1p 2 , Tds22p
ORF Classification Verified
Description Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion (1, 3, 4, 5, 6)
Name Description Multicopy Inhibitor of GAL gene expression 1
Experimental Data
Molecules/cell 830 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 504
Molecular Weight (Da) 55,532
Isoelectric Point (pI) 10.58

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mig1p (InterPro)
Physical Interactions There are 51 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F0FA | P27705
MIPS: YGL035C
NCBI: 127091 | 1322514 | 3437 | 3963 | 51013769 | 52695636 | 52695639 | 52695642 | 6321403 | NP_011480.1 | NM_001180900.1
GenBank/EMBL/DDBJ: DAA08065.1 | AY693159 | X55442 | X55734 | Z72557
Amino Acid Sequence (or in FASTA format)
 
       1  MQSPYPMTQV SNVDDGSLLK ESKSKSKVAA KSEAPRPHAC PICHRAFHRL
      51  EHQTRHMRIH TGEKPHACDF PGCVKRFSRS DELTRHRRIH TNSHPRGKRG
     101  RKKKVVGSPI NSASSSATSI PDLNTANFSP PLPQQHLSPL IPIAIAPKEN
     151  SSRSSTRKGR KTKFEIGESG GNDPYMVSSP KTMAKIPVSV KPPPSLALNN
     201  MNYQTSSAST ALSSLSNSHS GSRLKLNALS SLQMMTPIAS SAPRTVFIDG
     251  PEQKQLQQQQ NSLSPRYSNT VILPRPRSLT DFQGLNNANP NNNGSLRAQT
     301  QSSVQLKRPS SVLSLNDLLV GQRNTNESDS DFTTGGEDEE DGLKDPSNSS
     351  IDNLEQDYLQ EQSRKKSKTS TPTTMLSRST SGTNLHTLGY VMNQNHLHFS
     401  SSSPDFQKEL NNRLLNVQQQ QQEQHTLLQS QNTSNQSQNQ NQNQMMASSS
     451  SLSTTPLLLS PRVNMINTAI STQQTPISQS DSQVQELETL PPIRSLPLPF
     501  PHMD*

external links for Mig1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mig1p
1) Nehlin JO and Ronne H  (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J 9(9):2891-8
2) Carlson M, et al.  (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107(1):19-32
3) Lundin M, et al.  (1994) Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1. Mol Cell Biol 14(3):1979-85
4) Schuller HJ  (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60
5) Santangelo GM  (2006) Glucose signaling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 70(1):253-82
6) Karunanithi S and Cullen PJ  (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41