ALK1/YGL021W Protein Information Help

Standard Name Alk1p
Systematic Name Ygl021wp
ORF Classification Verified
Description Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins (1, 2, 3, 4)
Experimental Data
Molecules/cell 2190 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 760
Molecular Weight (Da) 86,086
Isoelectric Point (pI) 10.41

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Alk1p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000125859 | P43633
MIPS: YGL021W
NCBI: 1322487 | 1703251 | 6321417 | 861110 | NP_011494.1
GenBank/EMBL/DDBJ: DAA08077.1 | X87672 | Z72543
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MLLHFDIVIQ LLSSHTLKSH QVEPPMDFET SFEEFVEDKR FIALEVSDND
      51  DDCDTDLTAD TADELESSAI LKMRESDASL NVTTGNNTSR KTTSNSKKRW
     101  SLLSNHSAVS SSKSKKRWSV LSSSFTSESH KDRESRNVLQ QKRKSLQSYS
     151  SLDTVASNSS ISASSSLKRS STGLSLRQLF TKIGINDDIS QPGIGIPQGK
     201  ENLPPTMGKK NSSIASTSSE NRLRTPLKPL VNHSKRPTSQ PQQQQPLYNA
     251  SLSSRRSSIS STVSSSSSSK WRFWKRNKNQ TPALLQPDHH SLKTFPAVNR
     301  RDSMTPVEPR NMVKHKTSFS DFHKTIFSSN TYSESSDTIS SMEITLKNKA
     351  SSSSLSLNVL KKRNSQSSLK HKSSHASLQK FKRNKGKSSM IAPSTATNSS
     401  NDDSCSYSSK NSTLSHRISL PVPDQVSRDK IQNKLRYSTS LLSLNSKSSL
     451  PMNKNDHDET LLRQILLNCD IKRILNPAKG DVLPLINDVN HLSSIQLTSN
     501  VWQIGEVICK KVSLGTIDDI TWDRKFLSLQ ELEKLKIMQQ KFDGIPQLLK
     551  SFVVKEANGG LYLYLLFKDH GTPISLISLK NWKQILKIFW SCAGIIHGLE
     601  KNLKFEHRNL TLDNILIDGN GNITIIDFKC SRLQTPQDDV LYLRLDHPLF
     651  FLNGKDKSKI NEYQYQFEFE IYQSMRILLN MDASAFEPMT NLYWLYYLSR
     701  VLLKFGDRKL GKNDANRDKM ARVINHLEMN LAVHKRGGQL FKRLETEDIK
     751  NTGDLLKLYK *

external links for Alk1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Alk1p
1) Chen WN, et al.  (1991) The YGL021 gene encodes a putative membrane protein with a putative leucine zipper motif. Yeast 7(3):301-3
2) Higgins JM  (2003) Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-62
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Nespoli A, et al.  (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41