KAP122/YGL016W Protein Information Help

Standard Name Kap122p
Systematic Name Ygl016wp
Alias Pdr6p
ORF Classification Verified
Description Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance (1, 2)
Name Description KAryoPherin
Experimental Data
Molecules/cell 9760 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,081
Molecular Weight (Da) 123,530
Isoelectric Point (pI) 4.75

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kap122p (InterPro)
Physical Interactions There are 30 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001314D9 | P32767
MIPS: YGL016W
NCBI: 1322477 | 234320 | 417457 | 4261601 | 6321422 | NP_011499.1
GenBank/EMBL/DDBJ: DAA08082.1 | S57895 | S58126 | Z72538
Amino Acid Sequence (or in FASTA format)
 
       1  MSSIHEVVAL IEELYSPHPK HDVNQIQQSL QSIQKSEQGF HLANELLSDD
      51  KYSANVKYFG ALTLTVQLNT RGENDYETLW NVFRSNLLYL TKFSTLYVSN
     101  PNMYGQSLII IKKLMSNLSL IFTKINDPQL NNAGNENMIK QWNNPINTFI
     151  QLMSVQNQNI NADQLLLDSI NCSLTYEQLS QFVSLSQKHN ELALTFTEVI
     201  VEDLTKFQTK RHSMSQIHEV VHEHLYISTM ALINLNLTAQ AVFNPTVFDC
     251  ITAWINYISL TRSVSSSGRM DLSEIFQNLI DLMYQSTEGS DGYENAEKIL
     301  TIFGNVFAND PLLMSYDLRQ QIECIFLGVV RPDSGITDIS NKNSWMLQYM
     351  NYLVTNDFFS ELKELAICIV DFLQINTLSV CNKLFTNIQA ADNGQVQDEY
     401  IQEYIKVLLQ MTNFPLTPVL QEFFSVRMVD FWLDLSDAYT NLASETLRPN
     451  SIELSTQIFQ QLINIYLPKI SLSVKQRIIE EEGESTSVNE FEDFRNAVSD
     501  LAQSLWSILG NDNLTNVLID GMGQMPAASD ETLIIKDTDV LFRIETMCFV
     551  LNTILVDMTL SESPWIKNIV DANKFFNQNV ISVFQTGFQT SASTKVSQIL
     601  KLDFVRTSTT LIGTLAGYFK QEPFQLNPYV EALFQGLHTC TNFTSKNEQE
     651  KISNDKLEVM VIKTVSTLCE TCREELTPYL MHFISFLNTV IMPDSNVSHF
     701  TRTKLVRSIG YVVQCQVSNG PEEQAKYILQ LTNLLSGSIE HCLASSVQLQ
     751  EQQDYINCLL YCISELATSL IQPTEIIEND ALLQRLSEFQ SFWSSDPLQI
     801  RSKIMCTIDK VLDNSIYCKN SAFVEIGCLI VGKGLNLPDG EPYFLKYNMS
     851  EVMNFVLRHV PNCELATCLP YFVYLLEKLI SEFRKELTPQ EFDFMFEKIL
     901  LVYYDAYIIN DPDLLQMTIG FVNNVLDVKP GLAIGSKHWT SFILPQFLKL
     951  IPSREKFTIV AVAKFWTKLI NNKKYNQEEL TTVRQQVSSI GGDLVYQIMY
    1001  GLFHTQRSDL NSYTDLLRAL VAKFPIEARE WLVAVLPQIC NNPAGHEKFI
    1051  NKLLITRGSR AAGNVILQWW LDCTTLPNYQ G*

external links for Kap122p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Kap122p
1) Chen WN, et al.  (1991) The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Yeast 7(3):287-99
2) Titov AA and Blobel G  (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41