PDR1/YGL013C Protein Information Help

Standard Name Pdr1p
Systematic Name Ygl013cp
Alias Amy1p , Ant1p , Bor2p , Cyh3p , Nra2p , Smr2p , Til1p , Tpe1p , Tpe3p
ORF Classification Verified
Description Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication (1, 2)
Name Description Pleiotropic Drug Resistance
Experimental Data
Molecules/cell 1300 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,068
Molecular Weight (Da) 121,793
Isoelectric Point (pI) 6.91

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pdr1p (InterPro)
Physical Interactions There are 31 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000168331 | P12383
MIPS: YGL013C
NCBI: 129733 | 1322471 | 172112 | 190358909 | 6321425 | 7706833 | NP_011502.1
GenBank/EMBL/DDBJ: DAA08085.1 | J03487 | S58126 | Z72535
Amino Acid Sequence (or in FASTA format)
 
       1  MRGLTPKNGV HIETGPDTES SADSSNFSTG FSGKIRKPRS KVSKACDNCR
      51  KRKIKCNGKF PCASCEIYSC ECTFSTRQGG ARIKNLHKTS LEGTTVQVKE
     101  ETDSSSTSFS NPQRCTDGPC AVEQPTKFFE NFKLGGRSSG DNSGSDGKND
     151  DDVNRNGFYE DDSESQATLT SLQTTLKNLK EMAHLGTHVT SAIESIELQI
     201  SDLLKRWEPK VRTKELATTK FYPNKSIETQ LMKNKYCDVV HLTRYAAWSN
     251  NKKDQDTSSQ PLIDEIFGLY SPFQFLSLQG IGKCFQNYRS KSKCEIFPRT
     301  AKETIYIMLR FFDVCFHHIN QGCVSIANPL ENYLQKMNLL PSTPSSISSA
     351  GSPNTAHTKS HVALVINHLP QPFVRNITGI SNSELLSEMN NDISMFGILL
     401  KMLDMHKNSY QNFLMEITSN PSVAKNTQSI DVLQEFIHYC QAGEALIALC
     451  YSYYNSTLYN YVDFTCDITH LEQLLYFLDL LFWLSEIYGF EKVLNVAVHF
     501  VSRVGLSRWE FYVGLDENFA ERRRNLWWKA FYFEKTLASK LGYPSNIDDS
     551  KINCLLPKNF RDVGFLDNRD FIENVHLVRR SEAFDNMCIS DLKYYGELAV
     601  LQIVSHFSSS VLFNEKFTSI RNTSKPSVVR EKLLFEVLEI FNETEMKYDA
     651  IKEQTGKLFD IAFSKDSTEL KVSREDKIMA SKFVLFYEHH FCRMVNESDN
     701  IVARLCVHRR PSILIENLKI YLHKIYKSWT DMNKILLDFD NDYSVYRSFA
     751  HYSISCIILV SQAFSVAEFI KVNDVVNMIR VFKRFLDIKI FSENETNEHV
     801  FNSQSFKDYT RAFSFLTIVT RIMLLAYGES SSTNLDVISK YIDENAPDLK
     851  GIIELVLDTN SCAYRFLLEP VQKSGFHLTV SQMLKNRKFQ EPLMSNEDNK
     901  QMKHNSGKNL NPDLPSLKTG TSCLLNGIES PQLPFNGRSA PSPVRNNSLP
     951  EFAQLPSFRS LSVSDMINPD YAQPTNGQNN TQVQSNKPIN AQQQIPTSVQ
    1001  VPFMNTNEIN NNNNNNNNNK NNINNINNNN SNNFSATSFN LGTLDEFVNN
    1051  GDLEDLYSIL WSDVYPDS*

external links for Pdr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pdr1p
1) Akache B, et al.  (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41