PMC1/YGL006W Protein Information Help

Standard Name Pmc1p 1
Systematic Name Ygl006wp
ORF Classification Verified
Description Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a (1, 2)
Name Description Plasma Membrane Calcium 1, 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,173
Molecular Weight (Da) 130,860
Isoelectric Point (pI) 7.33

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pmc1p (InterPro)
Transmembrane Domains There are 9 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 38 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000126202 | P38929
MIPS: YGL006W
NCBI: 1322457 | 454003 | 6321432 | 728904 | NP_011509.1 | NM_001180871.1
GenBank/EMBL/DDBJ: DAA08093.1 | U03060 | Z72528
External Classifications EC: 3.6.3.8 [Calcium-transporting ATPase] TC: 3.A.3.2
Amino Acid Sequence (or in FASTA format)
 
       1  MSRQDENSAL LANNENNKPS YTGNENGVYD NFKLSKSQLS DLHNPKSIRS
      51  FVRLFGYESN SLFKYLKTDK NAGISLPEIS NYRKTNRYKN YGDNSLPERI
     101  PKSFLQLVWA AFNDKTMQLL TVAAVVSFVL GLYELWMQPP QYDPEGNKIK
     151  QVDWIEGVAI MIAVFVVVLV SAANDYQKEL QFAKLNKKKE NRKIIVIRND
     201  QEILISIHHV LVGDVISLQT GDVVPADCVM ISGKCEADES SITGESNTIQ
     251  KFPVDNSLRD FKKFNSIDSH NHSKPLDIGD VNEDGNKIAD CMLISGSRIL
     301  SGLGRGVITS VGINSVYGQT MTSLNAEPES TPLQLHLSQL ADNISVYGCV
     351  SAIILFLVLF TRYLFYIIPE DGRFHDLDPA QKGSKFMNIF ITSITVIVVA
     401  VPEGLPLAVT LALAFATTRM TKDGNLVRVL RSCETMGSAT AVCSDKTGTL
     451  TENVMTVVRG FPGNSKFDDS KSLPVSEQRK LNSKKVFEEN CSSSLRNDLL
     501  ANIVLNSTAF ENRDYKKNDK NTNGSKNMSK NLSFLDKCKS RLSFFKKGNR
     551  EDDEDQLFKN VNKGRQEPFI GSKTETALLS LARLSLGLQP GELQYLRDQP
     601  MEKFNIEKVV QTIPFESSRK WAGLVVKYKE GKNKKPFYRF FIKGAAEIVS
     651  KNCSYKRNSD DTLEEINEDN KKETDDEIKN LASDALRAIS VAHKDFCECD
     701  SWPPEQLRDK DSPNIAALDL LFNSQKGLIL DGLLGIQDPL RAGVRESVQQ
     751  CQRAGVTVRM VTGDNILTAK AIARNCAILS TDISSEAYSA MEGTEFRKLT
     801  KNERIRILPN LRVLARSSPE DKRLLVETLK GMGDVVAVTG DGTNDAPALK
     851  LADVGFSMGI SGTEVAREAS DIILMTDDFS AIVNAIKWGR CVSVSIKKFI
     901  QFQLIVNITA VILTFVSSVA SSDETSVLTA VQLLWINLIM DTLAALALAT
     951  DKPDPNIMDR KPRGRSTSLI SVSTWKMILS QATLQLIVTF ILHFYGPELF
    1001  FKKHEDEITS HQQQQLNAMT FNTFVWLQFF TMLVSRKLDE GDGISNWRGR
    1051  ISAANLNFFQ DLGRNYYFLT IMAIIGSCQV LIMFFGGAPF SIARQTKSMW
    1101  ITAVLCGMLS LIMGVLVRIC PDEVAVKVFP AAFVQRFKYV FGLEFLRKNH
    1151  TGKHDDEEAL LEESDSPEST AFY*

external links for Pmc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome TCDB
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Pmc1p
1) Cunningham KW and Fink GR  (1994) Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. J Cell Biol 124(3):351-63
2) Marchi V, et al.  (1999) Induction of vacuolar Ca2+-ATPase and H+/Ca2+ exchange activity in yeast mutants lacking Pmr1, the Golgi Ca2+-ATPase. FEBS Lett 454(3):181-6
3) Shull GE and Greeb J  (1988) Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases. J Biol Chem 263(18):8646-57