HSP31/YDR533C Protein Information

Standard Name	Hsp31p 1
Systematic Name	Ydr533cp
ORF Classification	Verified
Description	Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Heat-Shock Protein

Experimental Data
Molecules/cell	358 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	237
Molecular Weight (Da)	25,670
Isoelectric Point (pI)	5.2

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hsp31p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B53C \| Q04432 MIPS: YDR533C NCBI: 42543621 \| 45270564 \| 47168639 \| 47168640 \| 47168641 \| 47168642 \| 47168643 \| 47168644 \| 47168645 \| 47168646 \| 50400297 \| 6320742 \| 927800 \| NP_010822.1 GenBank/EMBL/DDBJ: DAA12364.1 \| AY558337 \| U33057
External Classifications	EC: 3.2.-.- [Glycosylases]

Amino Acid Sequence (or in FASTA format)
1 MAPKKVLLAL TSYNDVFYSD GAKTGVFVVE ALHPFNTFRK EGFEVDFVSE 51 TGKFGWDEHS LAKDFLNGQD ETDFKNKDSD FNKTLAKIKT PKEVNADDYQ 101 IFFASAGHGT LFDYPKAKDL QDIASEIYAN GGVVAAVCHG PAIFDGLTDK 151 KTGRPLIEGK SITGFTDVGE TILGVDSILK AKNLATVEDV AKKYGAKYLA 201 PVGPWDDYSI TDGRLVTGVN PASAHSTAVR SIDALKN*

Amino Acid Sequence (or in FASTA format)

       1  MAPKKVLLAL TSYNDVFYSD GAKTGVFVVE ALHPFNTFRK EGFEVDFVSE
      51  TGKFGWDEHS LAKDFLNGQD ETDFKNKDSD FNKTLAKIKT PKEVNADDYQ
     101  IFFASAGHGT LFDYPKAKDL QDIASEIYAN GGVVAAVCHG PAIFDGLTDK
     151  KTGRPLIEGK SITGFTDVGE TILGVDSILK AKNLATVEDV AKKYGAKYLA
     201  PVGPWDDYSI TDGRLVTGVN PASAHSTAVR SIDALKN*

external links for Hsp31p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hsp31p

1)	Wilson MA, et al. (2004) The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily. Proc Natl Acad Sci U S A 101(6):1531-6
2)	Goyal K and Mande SC (2008) Exploiting 3D structural templates for detection of metal-binding sites in protein structures. Proteins 70(4):1206-18
3)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41