CAB1/YDR531W Protein Information

Standard Name	Cab1p 1
Systematic Name	Ydr531wp
ORF Classification	Verified
Description	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element (2, 3)
Name Description	Coenzyme A Biosynthesis 1

Experimental Data
Molecules/cell	6190 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	367
Molecular Weight (Da)	40,903
Isoelectric Point (pI)	6.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cab1p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B72E \| Q04430 MIPS: YDR531W NCBI: 398366683 \| 74583483 \| 927798 \| NP_010820.3 GenBank/EMBL/DDBJ: DAA12362.1 \| U33057
External Classifications	EC: 2.7.1.33 [Pantothenate kinase]

Amino Acid Sequence (or in FASTA format)
1 MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE 51 KIDKFMELLH SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI 101 SRFEEMEGLI HGLDFFIHEI PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP 151 YLLVNIGSGV SILKVTEPNN FSRVGGSSLG GGTLWGLLSL ITGAQTYDQM 201 LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK VFQNRMTSNK 251 SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK 301 INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM 351 GAFLSASRHS STKKTST*

Amino Acid Sequence (or in FASTA format)

       1  MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE
      51  KIDKFMELLH SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI
     101  SRFEEMEGLI HGLDFFIHEI PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP
     151  YLLVNIGSGV SILKVTEPNN FSRVGGSSLG GGTLWGLLSL ITGAQTYDQM
     201  LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK VFQNRMTSNK
     251  SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK
     301  INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM
     351  GAFLSASRHS STKKTST*

external links for Cab1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cab1p

1)	Olzhausen J, et al. (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73
2)	Calder RB, et al. (1999) Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. J Biol Chem 274(4):2014-20
3)	Brohee S, et al. (2011) Unraveling networks of co-regulated genes on the sole basis of genome sequences. Nucleic Acids Res 39(15):6340-58
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41