SPS1/YDR523C Protein Information

Standard Name	Sps1p 1
Systematic Name	Ydr523cp
ORF Classification	Verified
Description	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis (2, 3)
Name Description	SPorulation Specific 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	490
Molecular Weight (Da)	55,704
Isoelectric Point (pI)	7.65

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sps1p (InterPro)
Physical Interactions	There are 56 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135E83 \| P08458 MIPS: YDR523C NCBI: 1174431 \| 172671 \| 535320 \| 6320731 \| 927791 \| NP_010811.1 GenBank/EMBL/DDBJ: DAA12353.1 \| M13629 \| U13018 \| U33057
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MESKEISIRS RTPPSKLYSI QSCIGRGNFG DVYKAVDRVT QEIVAIKVVN 51 LEHSDEDIEL LAQEIFFLAE LKSPLITNYI ATMLEDVSMW IVMEYCGGGS 101 CSDLLKRSYV NGLPEEKVSF IIHEVTLGLK YLHEQRKIHR DIKAANILLN 151 EEGMVKLGDF GVSGHIRSTL KRDTFVGTPY WMAPEVVCCE VDGYNEKADI 201 WSLGITTYEL LKGLPPLSKY DPMKVMTNLP KRKPPKLQGP FSDAAKDFVA 251 GCLVKTPADR PSAYNLLSFE FVKNITITNL KSDVDLIKQK KVQERYTKVP 301 KYPLQNRLYK NSNTVRGKEF WNFESTRLST TQISKEELSP ITQDSPTSSL 351 NMESPYLLHG QTVTPITNPS SSSFRKCTQP VFELDSGMDI DSGCPNAQAE 401 TEIVPLSNHN KKHKKNDIQA LKIEKFDYLK NIVSHILNRM YDRARDDETR 451 KYVNEMLKQF IKTEANVPGF NEVFIEEISL RIEAIKKGFV *

Amino Acid Sequence (or in FASTA format)

       1  MESKEISIRS RTPPSKLYSI QSCIGRGNFG DVYKAVDRVT QEIVAIKVVN
      51  LEHSDEDIEL LAQEIFFLAE LKSPLITNYI ATMLEDVSMW IVMEYCGGGS
     101  CSDLLKRSYV NGLPEEKVSF IIHEVTLGLK YLHEQRKIHR DIKAANILLN
     151  EEGMVKLGDF GVSGHIRSTL KRDTFVGTPY WMAPEVVCCE VDGYNEKADI
     201  WSLGITTYEL LKGLPPLSKY DPMKVMTNLP KRKPPKLQGP FSDAAKDFVA
     251  GCLVKTPADR PSAYNLLSFE FVKNITITNL KSDVDLIKQK KVQERYTKVP
     301  KYPLQNRLYK NSNTVRGKEF WNFESTRLST TQISKEELSP ITQDSPTSSL
     351  NMESPYLLHG QTVTPITNPS SSSFRKCTQP VFELDSGMDI DSGCPNAQAE
     401  TEIVPLSNHN KKHKKNDIQA LKIEKFDYLK NIVSHILNRM YDRARDDETR
     451  KYVNEMLKQF IKTEANVPGF NEVFIEEISL RIEAIKKGFV *

external links for Sps1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sps1p

1)	Percival-Smith A and Segall J (1986) Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae. Mol Cell Biol 6(7):2443-51
2)	Friesen H, et al. (1994) Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation. Genes Dev 8(18):2162-75
3)	Iwamoto MA, et al. (2005) Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Eukaryot Cell 4(3):536-44