URC2/YDR520C Protein Information Help

Standard Name Urc2p 1
Systematic Name Ydr520cp
Alias Rrt4p 2
ORF Classification Uncharacterized
Description Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism (1, 2, 3, 4)
Name Description URacil Catabolism 1
Experimental Data
Molecules/cell 937 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 772
Molecular Weight (Da) 88,647
Isoelectric Point (pI) 7.9

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Urc2p (InterPro)
Physical Interactions There are 14 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006B8B0 | Q04411
MIPS: YDR520C
NCBI: 398366673 | 51012889 | 74676359 | 927789 | NP_010808.3
GenBank/EMBL/DDBJ: DAA12351.1 | AY692719 | U33057
Amino Acid Sequence (or in FASTA format)
 
       1  MDINSNASVS PRPDGLPMTA GYNSASGKVR NSIRSIINHP EDSARAKERS
      51  ETNSPKNNGN KKPRKKRKTF SCDTCRRVKT RCDFEPFIGK CYRCNVLQLD
     101  CSLARNKDNE ILNTLREDGL LKKINSINHN LGSFSHLNAD SPNESQSSFE
     151  KNGTVNFDNY MIDKRLSSLE EHIKSLHQKM DLIITTAKMS YNSDIKGPGD
     201  DIQNVDFSSN KTYDSRLTSG SETIRKTGEY RKENLFLNGF KLKESPLKLL
     251  HDIDERLFPS KATSKAAKLA GQQRPYAVAR VNFLHFYENN QELCHKLAKE
     301  FLVRSHFWII PGGRKEIDVE YAHSHLFITS VFTIIAMSFA DNDKYAAEQE
     351  ILYPLVERLL TNTLTMFEKL TAFDIEAILY CCMFHISRKA KRYRQLKFNS
     401  LVLSNFALNS LLHVIDFYQI KDRVLVKEVY NPEDLYHLRI LNSLTACYLE
     451  YSISYGDIRE QDDMLKEFNK LVAKFPQANF GDDIKISEIN LGDIVNGIFI
     501  NLKNYFAQCL DDFNNDRYGG NADTFIFVFP ELNYWLKNWE ELLAKDGAGV
     551  LLFTFDFYHI MICRTFITEF SSTLKSNQRF LKLILNTMKE HSFSLLNGFL
     601  RLPPTLIRGA PIFTCHQLVY ACLTLCDYLY WFDSSERQRV LSLCTKVYWH
     651  LSTIGEKMNE ATDNVGKIIK SIIDTSKTRI NFGSLSKENS DNDKMSTNAN
     701  NYTGAGNLHA AKPATSPTNV GTLHENLSSS HFMIPDVDQF NSFEDFFQDF
     751  FDSLKPNSQK MFTSDKKTEQ TT*

external links for Urc2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Urc2p
1) Andersen G, et al.  (2008) A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes. J Mol Biol 380(4):656-66
2) Hontz RD, et al.  (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
3) Akache B, et al.  (2001) Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res 29(10):2181-90
4) Guo X, et al.  (2006) Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae. Bioinformatics 22(4):392-9
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41