EUG1/YDR518W Protein Information

Standard Name	Eug1p 1
Systematic Name	Ydr518wp
ORF Classification	Verified
Description	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER (1, 2, 3)
Name Description	ER protein Unnecessary for Growth 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	517
Molecular Weight (Da)	58,982
Isoelectric Point (pI)	4.63

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Eug1p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C40 \| P32474 MIPS: YDR518W NCBI: 416977 \| 488151 \| 51013391 \| 6320726 \| 927787 \| NP_010806.1 GenBank/EMBL/DDBJ: DAA12349.1 \| AY692970 \| M84796 \| U33057
External Classifications	EC: 5.3.4.1 [Protein disulfide-isomerase]

Amino Acid Sequence (or in FASTA format)
1 MQVTTRFISA IVSFCLFASF TLAENSARAT PGSDLLVLTE KKFKSFIESH 51 PLVLVEFFAP WCLHSQILRP HLEEAASILK EHNVPVVQID CEANSMVCLQ 101 QTINTYPTLK IFKNGRIFDG QVYRGVKITD EITQYMIQLY EASVIYLNSE 151 DEIQPYLENA TLPVVINRGL TGLNETYQEV ALDLAEDYVF LSLLDSEDKS 201 LSIHLPNTTE PILFDGNVDS LVGNSVALTQ WLKVVILPYF TDIEPDLFPK 251 YISSNLPLAY FFYTSEEELE DYTDLFTQLG KENRGQINFI ALNSTMFPHH 301 VRFLNMREQF PLFAIHNMIN NLKYGLPQLP EEEYAKLEKP QPLDRDMIVQ 351 LVKDYREGTA KPIVKSEEIP KEQKSNVYKI VGKTHDDIVH DDDKDVLVKY 401 YATWCIHSKR FAPIYEEIAN VLASDESVRD KILIAEVDSG ANDILSFPVT 451 GYPTIALYPA GNNSKPIIFN KIRNLEDVFE FIKESGTHHI DGQAIYDKLH 501 QAKDSEVSTE DTVHDEL*

Amino Acid Sequence (or in FASTA format)

       1  MQVTTRFISA IVSFCLFASF TLAENSARAT PGSDLLVLTE KKFKSFIESH
      51  PLVLVEFFAP WCLHSQILRP HLEEAASILK EHNVPVVQID CEANSMVCLQ
     101  QTINTYPTLK IFKNGRIFDG QVYRGVKITD EITQYMIQLY EASVIYLNSE
     151  DEIQPYLENA TLPVVINRGL TGLNETYQEV ALDLAEDYVF LSLLDSEDKS
     201  LSIHLPNTTE PILFDGNVDS LVGNSVALTQ WLKVVILPYF TDIEPDLFPK
     251  YISSNLPLAY FFYTSEEELE DYTDLFTQLG KENRGQINFI ALNSTMFPHH
     301  VRFLNMREQF PLFAIHNMIN NLKYGLPQLP EEEYAKLEKP QPLDRDMIVQ
     351  LVKDYREGTA KPIVKSEEIP KEQKSNVYKI VGKTHDDIVH DDDKDVLVKY
     401  YATWCIHSKR FAPIYEEIAN VLASDESVRD KILIAEVDSG ANDILSFPVT
     451  GYPTIALYPA GNNSKPIIFN KIRNLEDVFE FIKESGTHHI DGQAIYDKLH
     501  QAKDSEVSTE DTVHDEL*

external links for Eug1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Eug1p

1)	Tachibana C and Stevens TH (1992) The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase. Mol Cell Biol 12(10):4601-11
2)	Holst B, et al. (1997) Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum. J Cell Biol 138(6):1229-38
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61