GRX2/YDR513W Protein Information Help

Standard Name Grx2p 1
Systematic Name Ydr513wp
Alias Ttr1p 2
ORF Classification Verified
Description Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication (1, 3, 4, 5, 6, 7, 8)
Name Description GlutaRedoXin 1
Experimental Data
Molecules/cell 31400 9
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 143
Molecular Weight (Da) 15,861
Isoelectric Point (pI) 7.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Grx2p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 14 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F902 | P17695
MIPS: YDR513W
NCBI: 210060958 | 210060959 | 210060960 | 212374954 | 212374955 | 256163 | 417072 | 51013243 | 6320720 | 88984204 | 927781 | NP_010801.1
GenBank/EMBL/DDBJ: DAA12344.1 | AY692896 | S45268 | U33057
Amino Acid Sequence (or in FASTA format)
 
       1  METNFSFDSN LIVIIIITLF ATRIIAKRFL STPKMVSQET VAHVKDLIGQ
      51  KEVFVAAKTY CPYCKATLST LFQELNVPKS KALVLELDEM SNGSEIQDAL
     101  EEISGQKTVP NVYINGKHIG GNSDLETLKK NGKLAEILKP VFQ*

external links for Grx2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Grx2p
1) Luikenhuis S, et al.  (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91
2) Gan ZR  (1992) Cloning and sequencing of a gene encoding yeast thioltransferase. Biochem Biophys Res Commun 187(2):949-55
3) Grant CM, et al.  (2000) Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1490(1-2):33-42
4) Rodriguez-Manzaneque MT, et al.  (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90
5) Draculic T, et al.  (2000) A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae. Mol Microbiol 36(5):1167-74
6) Gan ZR, et al.  (1990) Complete amino acid sequence of yeast thioltransferase (glutaredoxin). Biochem Biophys Res Commun 168(3):944-51
7) Collinson EJ, et al.  (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
9) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41