GIN4/YDR507C Protein Information Help

Standard Name Gin4p
Systematic Name Ydr507cp
Alias Erc47p
ORF Classification Verified
Description Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Growth Inhibitory 1
Experimental Data
Molecules/cell 736 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,142
Molecular Weight (Da) 129,857
Isoelectric Point (pI) 10

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gin4p (InterPro)
Physical Interactions There are 132 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000036C3E | Q12263
MIPS: YDR507C
NCBI: 2499618 | 398366661 | 927777 | 992651 | NP_010795.3 | NM_001180815.3
GenBank/EMBL/DDBJ: DAA12339.1 | U33057 | U33140
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MAINGNSIPA IKDNTIGPWK LGETLGLGST GKVQLARNGS TGQEAAVKVI
      51  SKAVFNTGNV SGTSIVGSTT PDALPYGIER EIIIMKLLNH PNVLRLYDVW
     101  ETNTDLYLVL EYAEKGELFN LLVERGPLPE HEAIRFFRQI IIGVSYCHAL
     151  GIVHRDLKPE NLLLDHKYNI KIADFGMAAL ETEGKLLETS CGSPHYAAPE
     201  IVSGIPYQGF ASDVWSCGVI LFALLTGRLP FDEEDGNIRT LLLKVQKGEF
     251  EMPSDDEISR EAQDLIRKIL TVDPERRIKT RDILKHPLLQ KYPSIRDSKS
     301  IRGLPREDTY LTPLSESNSS IDATILQNLV ILWHGRDPEG IKEKLREPGA
     351  NAEKTLYALL YRFKCDTQKE LIKQQQVKKR QSISSVSVSP SKKVSTTPQR
     401  RRNRESLISV TSSRKKPISF NKFTASSASS SNLTTPGSSK RLSKNFSSKK
     451  KLSTIVNQSS PTPASRNKRA SVINVEKNQK RASIFSTTKK NKRSSRSIKR
     501  MSLIPSMKRE SVTTKLMSTY AKLAEDDDWE YIEKETKRTS SNFATLIDEI
     551  FEYEKYEQIR KEKEELERKV REAKAREELE RRRRKQEEKE RARKLLEKED
     601  LKRKQEELKK QIEIDISDLE QELSKHKEEK LDGNIRSISA PMENEEKNIN
     651  HLEVDIDNIL RRRNFSLQTR PVSRLDPGIM FSSPTEEVSP VEPKRTENER
     701  LTTEKKILET IRRSKFLGSS FNIDKELKLS KMEYPSIIAP QRLSEERVVS
     751  DSNDGYESLI LPKDGNGVSQ LKDSTATTAP VSDGRLRKIS EIRVPQFTRK
     801  SRHFSESNKR LSVLSMYSTK ESFTNLVDIL KNGNLDVNNQ QSQRIPTPRS
     851  ADDSEFLFET VNEEAEYTGN SSNDERLYDV GDSTIKDKSA LKLNFADRFN
     901  GSNEAKQTDN LHLPILPPLN GDNELRKQNS QEGDQAHPKI KSMIPESGSS
     951  SHTEKEEENE EKEEKKPEQH KQEEDQEKRE KVVDDMEPPL NKSVQKIREK
    1001  NAGSQAKDHS KDHLKEHKQD KNTAIGNGSF FRKFSKSSDK TMELYAKISA
    1051  KQLFNGLEKL LRGWTQYGLK NIKSHPNNLT LTGKLSSDNI FSLRSTLFEV
    1101  NIYPRGKMSV VQFKKVSGSF KAVKKLVNEV ENVLNKEGVL QK*

external links for Gin4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Gin4p
1) Altman R and Kellogg D  (1997) Control of mitotic events by Nap1 and the Gin4 kinase. J Cell Biol 138(1):119-30
2) Okuzaki D, et al.  (2003) The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 78(2):113-26
3) Iwase M and Toh-e A  (2004) Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. Cell Struct Funct 29(1):1-15
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41