ITR1/YDR497C Protein Information Help

Standard Name Itr1p
Systematic Name Ydr497cp
ORF Classification Verified
Description Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description myo-Inositol TRansporter 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 584
Molecular Weight (Da) 63,569
Isoelectric Point (pI) 6.51

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Itr1p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 28 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012DA4D | P30605
MIPS: YDR497C
NCBI: 1708578 | 218437 | 6320705 | 927767 | NP_010785.1
GenBank/EMBL/DDBJ: DAA12329.1 | D90352 | U33057
External Classifications TC: 2.A.1.1 [The Sugar Porter (SP) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ
      51  RAPASDDEDR IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF
     101  GYDTGYISSA LISIGTDLDH KVLTYGEKEI VTAATSLGAL ITSIFAGTAA
     151  DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW QMAVGRLIMG FGVGIGSLIA
     201  PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY VNNGWRILVG
     251  LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER
     301  KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF
     351  TGWNSLMYFS GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR
     401  TILLIGLPGM TMALVVCSIA FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF
     451  IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI GTSYATATNW AGSLVIASTF
     501  LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE EVQTILKDGF
     551  NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI*

external links for Itr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Itr1p
1) Lai K and McGraw P  (1994) Dual control of inositol transport in Saccharomyces cerevisiae by irreversible inactivation of permease and regulation of permease synthesis by INO2, INO4, and OPI1. J Biol Chem 269(3):2245-51
2) Nikawa J, et al.  (1991) Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J Biol Chem 266(17):11184-91
3) Nikawa J, et al.  (1993) Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Mol Microbiol 10(5):955-61
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76