IZH1/YDR492W Protein Information

Standard Name	Izh1p 1
Systematic Name	Ydr492wp
ORF Classification	Verified
Description	Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication (1, 2)
Name Description	Implicated in Zinc Homeostasis 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	316
Molecular Weight (Da)	36,491
Isoelectric Point (pI)	8.47

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Izh1p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B9A1 \| Q03419 MIPS: YDR492W NCBI: 45270876 \| 6320699 \| 74583416 \| 927736 \| NP_010780.1 \| NM_001180800.1 GenBank/EMBL/DDBJ: DAA12324.1 \| AY558493 \| U33050

Amino Acid Sequence (or in FASTA format)
1 MSITTTRRRN QDSVCCKATR ASIKVEAVSG QTVFEKQKLL HNFDELPEWQ 51 KDNDKILTGY VRETLSWKKC LYSLFYWNNE TVNIYTHLVP AIVYFVFAIT 101 LTNYFLIPVF PSTSWSDYTV INIFLMGAFS CLMCSSCFHC MKQHSEKQSN 151 FWSKLDYLGI ISLISCSMIP IIYFGYFDHI SYFSLFTIVT LVLATFCTVC 201 VLHDKFNTST FRPFRAMFFI LFGFSGLLPL TTGFFKFGIQ GVLNRIKVSF 251 VFWEALFYIS GAVIYGFRIP ETLAPGKFDF FGSSHQIFHI MVVLGSVCHL 301 KAIIDSYKLM HSHIHP*

Amino Acid Sequence (or in FASTA format)

       1  MSITTTRRRN QDSVCCKATR ASIKVEAVSG QTVFEKQKLL HNFDELPEWQ
      51  KDNDKILTGY VRETLSWKKC LYSLFYWNNE TVNIYTHLVP AIVYFVFAIT
     101  LTNYFLIPVF PSTSWSDYTV INIFLMGAFS CLMCSSCFHC MKQHSEKQSN
     151  FWSKLDYLGI ISLISCSMIP IIYFGYFDHI SYFSLFTIVT LVLATFCTVC
     201  VLHDKFNTST FRPFRAMFFI LFGFSGLLPL TTGFFKFGIQ GVLNRIKVSF
     251  VFWEALFYIS GAVIYGFRIP ETLAPGKFDF FGSSHQIFHI MVVLGSVCHL
     301  KAIIDSYKLM HSHIHP*

external links for Izh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Izh1p

1)	Lyons TJ, et al. (2004) Metalloregulation of yeast membrane steroid receptor homologs. Proc Natl Acad Sci U S A 101(15):5506-11
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61