VPS72/YDR485C Protein Information Help

Standard Name Vps72p
Systematic Name Ydr485cp
Alias Swc2p
ORF Classification Verified
Description Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting (1, 2, 3)
Name Description Vacuolar Protein Sorting 1
Experimental Data
Molecules/cell 358 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 795
Molecular Weight (Da) 90,579
Isoelectric Point (pI) 4.93

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vps72p (InterPro)
Physical Interactions There are 54 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001D4776 | Q03388
MIPS: YDR485C
NCBI: 398366639 | 51013757 | 62901397 | 927756 | NP_010773.4
GenBank/EMBL/DDBJ: DAA12318.1 | AY693153 | U33050
Amino Acid Sequence (or in FASTA format)
 
       1  MSDEGADKSL DTNTEFIIQT RSRRSNAGNK LQKLLEQELR DIESTKRQIS
      51  SYKNGNDDEE DEIGLLFQED EDDEDFEMMA KDDDDEGEEK EDETQSIRKE
     101  PSQASSEQAA DDLMFSSSES EDSSNENDED AEEKEIRRQE LLSRKKRNKR
     151  LQKGPVVIKK QKPKPKSGEA IPRSHHTHEQ LNAETLLLNT RRTSKRSSVM
     201  ENTMKVYEKL SKAEKKRKII QERIRKHKEQ ESQHMLTQEE RLRIAKETEK
     251  LNILSLDKFK EQEVWKKENR LALQKRQKQK FQPNETILQF LSTAWLMTPA
     301  MELEDRKYWQ EQLNKRDKKK KKYPRKPKKN LNLGKQDASD DKKRESEESI
     351  KNDGDVNSLG ENSSSVHNQK RIEETSTNDT VEGESSPDAA VSRVNSDELK
     401  PTALPDVTLD AIANKQSTVD EAPNSQPQKN IITNEQKITN VGEPIQNLHN
     451  EEIKDEMVSA LESRENTFEN SSPAAQVVSQ RDNSATPTPS NSTGTEDTIL
     501  ISPDTDIKGE PEPCLKTEGI ENLSHNVPQE TKSNTDVSFL KQVTFTDHPQ
     551  VAIIDTEESP SKKDTANVDE SSAENSLSTQ TYEGPEQLTS RNFVTLYDFP
     601  NAPPNLKDFN TNLFGDRWSY TNGLSATQRP QDMKTVFHSI LPSPPQSSVP
     651  SPTVDISLDL SALANFPSFG EYDKKIVHQI NTEINKDLEI KIKTQPPTGV
     701  FLANGIRKKC LITNKECQYF DPRTGVPYSD VEAYKIIQRI QDPISKEEGR
     751  SDIKRDETTN EDSDDQVRFK WFGFKNGGIY LDLSQRPAKG VPEGF*

external links for Vps72p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Vps72p
1) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
2) Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71
3) Watanabe S, et al.  (2013) A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science 340(6129):195-9
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41