SNF1/YDR477W Protein Information 
| Standard Name | Snf1p 1 |
|---|---|
| Systematic Name | Ydr477wp |
| Alias | Cat1p 2 , Ccr1p 3 , Glc2p 4 , Haf3p 5 , Pas14p 6 |
| ORF Classification | Verified |
| Description | AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation (10, 7, 8, 9) |
| Name Description | Sucrose NonFermenting 11 |
| Experimental Data | |
|---|---|
| Molecules/cell | 589 12 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Snf1p (InterPro) |
| Physical Interactions | There are 349 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000052F22 | P06782 MIPS: YDR477W NCBI: 134588 | 158430318 | 158430321 | 172630 | 238828139 | 238828140 | 242556806 | 242556807 | 306991744 | 356624533 | 356624589 | 356624592 | 398366631 | 927732 | 93279511 | NP_010765.3 GenBank/EMBL/DDBJ: DAA12310.1 | M13971 | U33050 |
| External Classifications | EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] |
external links for Snf1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA | ||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Snf1p
| 1) | Celenza JL and Carlson M (1984) Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol 4(1):49-53 |
| 2) | Zimmermann FK, et al. (1977) Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Mol Gen Genet 151(1):95-103 |
| 3) | Ciriacy M (1977) Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite derepression. Mol Gen Genet 154(2):213-20 |
| 4) | Cannon JF, et al. (1994) Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae. Genetics 136(2):485-503 |
| 5) | Kuchin SV, et al. (1993) Genes required for derepression of an extracellular glucoamylase gene, STA2, in the yeast Saccharomyces. Yeast 9(5):533-41 |
| 6) | Van der Leij I, et al. (1992) Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure. J Cell Biol 119(1):153-62 |
| 7) | Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 |
| 8) | Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 |
| 9) | Karunanithi S and Cullen PJ (2012) The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87 |
| 10) | Fernandez-Garcia P, et al. (2012) Phosphorylation of yeast hexokinase 2 regulates its nucleocytoplasmic shuttling. J Biol Chem 287(50):42151-64 |
| 11) | Carlson M, et al. (1981) Mutants of yeast defective in sucrose utilization. Genetics 98(1):25-40 |
| 12) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
