PKH3/YDR466W Protein Information Help

Standard Name Pkh3p
Systematic Name Ydr466wp
ORF Classification Verified
Description Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant (1)
Name Description Pkb-activating Kinase Homolog
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 898
Molecular Weight (Da) 100,475
Isoelectric Point (pI) 10.32

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pkh3p (InterPro)
Physical Interactions There are 43 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006C12E | Q03306
MIPS: YDR466W
NCBI: 6320674 | 74676345 | 927730 | NP_010754.1
GenBank/EMBL/DDBJ: DAA12301.1 | U33050
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTSRKRSPHD FIFKEELGHG SYSTVFKALD KKSPNKIYAI KVCSKKHIIK
      51  EAKVKYVTIE KNTMNLLAQK HHAGIIKLYY TFHDEENLYF VLDFAPGGEL
     101  LSLLHKMGTF NDIWTRHFTA QLIDALEFIH SHGIIHRDLK PENVLLDRDG
     151  RLMITDFGAA ATIDPSLSGD SAKFNSDSNG SKDNQNCASF VGTAEYVSPE
     201  LLLYNQCGYG SDIWALGCMI YQFVQGQPPF RGENELKTFE KIVALDYPWG
     251  PNNRINNSTS PINPLVINLV QKILVIEVNE RISLEQIKRH PYFSKVDWND
     301  KIKIWRGIWQ SQGQSLQQTT LGLPNIPQNI LPTRQLHVID TPARSIQITK
     351  QKRKKPTKIS NTTSSIVVWR KRLGISTGKD DLGTVPSTTP AVTAPNDTNV
     401  LTNTAAHSTA NIALPPNSQS NQVKRAQLVA PNRIPPKVPV INDNVRNKSI
     451  PRTKPNVPPL QTSSIPQKLS TSSASSALSA PSTEIRNQDL THTLDGRNSI
     501  DIHVLKQDYV FIYGIPYEHE GPAMSLNSYN KIDNDLITSL VAQHKEELKN
     551  SESFLQVLTL KKSGMLSYKN TVMEGNDDQE NKEHQMANIE DTDLSMYDFE
     601  FNELTRKGFL ILEKYKNRIW FISLPSYSTL SKIPFNAVKS STINNNENWV
     651  DCFFRARQLL EEKQILDKIS NVSFDSKASS EPSSPPPISR KERPLSIGNN
     701  VTTLSYTAKN GSQNNAPQND NVGEEKPFRI PSSTKDRPGA NSTPSSRHPR
     751  VLSSNNAGET PKKMNGRLPN SAPSTNTYTN GSVPAFNHRP STNVGNNKHN
     801  ILTSKKQGSS VFSPSSSTTK PQIKTTGYRQ PTPSPPLPQM EFPTTREKYS
     851  APSNMVISSS RYEVLHTLNN SQTNFDREIA SRGASAAFRS LQKSKKKK*

external links for Pkh3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Pkh3p
1) Inagaki M, et al.  (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52