SPP41/YDR464W Protein Information

Standard Name	Spp41p 1
Systematic Name	Ydr464wp
ORF Classification	Verified
Description	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 (1)
Name Description	Suppressor of PrP4 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,435
Molecular Weight (Da)	161,596
Isoelectric Point (pI)	9.69

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Spp41p (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A54A \| P38904 MIPS: YDR464W NCBI: 398366621 \| 435023 \| 56757612 \| 927729 \| NP_010752.3 GenBank/EMBL/DDBJ: DAA12299.1 \| U03673 \| U33050

Amino Acid Sequence (or in FASTA format)
1 MAYDEDDGEI NFNELVGNLL SSHNQEGQEE GEVQGGEQEG DDFEKIYPTS 51 ENIEPKHPDD SQHMHNSPDQ NIEIPHFVDE EDELVSVVAN AVQNIDDEQA 101 KPENHLENGS EHVTSDTADD NHEKEQQQEW AHILQQEILK SDGEPLRENT 151 ERRVSTSQHH PSQRTDDALD QDDENLRMAI LESLQELNTN EEEEKEPEKH 201 EHAAPNDKLS SKKSSKKKKK DKSKNRESSK DKSSKKSKSS SHSKKHAKDR 251 NKEKQSKPTN NENTLDLSNI LENLIHENDN AAIDTAKQTV DIQDNSHTDN 301 TNNEDVEAQA LVEATLKAFE NELLSSAPTE EPSQEQSIGP VSSRKAVEPP 351 RKPTADDIPL AMLQAFKPKK RPPQEKKKTK SKTSKAASTA NKSPASESTS 401 KKKKKKKTVK ESNKSQEAYE DDEFSRILAD MVNQVVNTSL KETSTHTATQ 451 DNKLESESDF TSPVQSQYTT EDASTANDDS LDLNQIMQNA MAMVFQNQND 501 DEFDENIVED FNRGLGDLSV SDLLPHDNLS RMEKKSVPKS SSKSEKKTAI 551 SRRASKKASR DASSVELTEV PSKPKKPSKT EVSLEKKLRK KYVSIANEAA 601 SVARKKRWAK NKELKEKEKL ERQTAREERR HKKKLEKQRL AEEQEELKKI 651 VERGPPYPPD LRLTKSGKPK KPYRRWTPEE LLKRSQEAEK PRKVKKERKK 701 KEKKMKVPSS ALKKIPLFNF VKGNVQPSAR HRLNDIEGSL STIGLHKSPD 751 GVRRILSRPK SEDHEWPLSD SSASQNYDAH LKTVVHKEKI PFHPPWTIPS 801 QPPFALPVAR RKKIPNIKKY RKRTNNSFRV SKEGTASTRN RILPAILLPI 851 INTLKAAAKS QTAAGATPEE ARKRLATIIQ HAKSTVIRAA LQARKNSMQA 901 AHSKGTTTEL ATTASRMKNP LKMIPIFNTS RVKQQLDKQL PARSAGTEIS 951 SSESPDKATP DPHSNSTIAG HTLKGVTTPI KIEDSDANVP PVSIAVSTIE 1001 PSQDKLELTK RAESVEPVEN NVETAKETQS VQEIKENVGT KASEEVTLTE 1051 DKTNGDPKNE KRILIESPVE KTDKKKPGEK IATDLNEDAS LSDKKDGDEK 1101 STLHSDAAQL TGNEPDSVNT TTGKPKLIDV SLKPLNEAKP KIPIIFPLKR 1151 PQIKPEVSVI NLVQNLVNTK IPEIKNESVD LGSNITDILS STITNILPEI 1201 TATDVKNYQY EDENVKYLKK TPRQVLNLDG LVPPSGRCIT KAKRVRRIKK 1251 LSADATTAPE ADGKANSESI TYTFDIPSPE EVQSKRSVVL KFAKARLTEA 1301 ELSCLKKEIN NVRKRRWREM NSTKNWEYDV KSRLKKRANA FFGEGESETK 1351 SKWIEERFQE KVSQEKYKDR LETTETQANN TKIVIDDKEI LNILAVNMNN 1401 LNKARCIEKD IQESFREEKL ASLQPKKKRK KSILH*

Amino Acid Sequence (or in FASTA format)

       1  MAYDEDDGEI NFNELVGNLL SSHNQEGQEE GEVQGGEQEG DDFEKIYPTS
      51  ENIEPKHPDD SQHMHNSPDQ NIEIPHFVDE EDELVSVVAN AVQNIDDEQA
     101  KPENHLENGS EHVTSDTADD NHEKEQQQEW AHILQQEILK SDGEPLRENT
     151  ERRVSTSQHH PSQRTDDALD QDDENLRMAI LESLQELNTN EEEEKEPEKH
     201  EHAAPNDKLS SKKSSKKKKK DKSKNRESSK DKSSKKSKSS SHSKKHAKDR
     251  NKEKQSKPTN NENTLDLSNI LENLIHENDN AAIDTAKQTV DIQDNSHTDN
     301  TNNEDVEAQA LVEATLKAFE NELLSSAPTE EPSQEQSIGP VSSRKAVEPP
     351  RKPTADDIPL AMLQAFKPKK RPPQEKKKTK SKTSKAASTA NKSPASESTS
     401  KKKKKKKTVK ESNKSQEAYE DDEFSRILAD MVNQVVNTSL KETSTHTATQ
     451  DNKLESESDF TSPVQSQYTT EDASTANDDS LDLNQIMQNA MAMVFQNQND
     501  DEFDENIVED FNRGLGDLSV SDLLPHDNLS RMEKKSVPKS SSKSEKKTAI
     551  SRRASKKASR DASSVELTEV PSKPKKPSKT EVSLEKKLRK KYVSIANEAA
     601  SVARKKRWAK NKELKEKEKL ERQTAREERR HKKKLEKQRL AEEQEELKKI
     651  VERGPPYPPD LRLTKSGKPK KPYRRWTPEE LLKRSQEAEK PRKVKKERKK
     701  KEKKMKVPSS ALKKIPLFNF VKGNVQPSAR HRLNDIEGSL STIGLHKSPD
     751  GVRRILSRPK SEDHEWPLSD SSASQNYDAH LKTVVHKEKI PFHPPWTIPS
     801  QPPFALPVAR RKKIPNIKKY RKRTNNSFRV SKEGTASTRN RILPAILLPI
     851  INTLKAAAKS QTAAGATPEE ARKRLATIIQ HAKSTVIRAA LQARKNSMQA
     901  AHSKGTTTEL ATTASRMKNP LKMIPIFNTS RVKQQLDKQL PARSAGTEIS
     951  SSESPDKATP DPHSNSTIAG HTLKGVTTPI KIEDSDANVP PVSIAVSTIE
    1001  PSQDKLELTK RAESVEPVEN NVETAKETQS VQEIKENVGT KASEEVTLTE
    1051  DKTNGDPKNE KRILIESPVE KTDKKKPGEK IATDLNEDAS LSDKKDGDEK
    1101  STLHSDAAQL TGNEPDSVNT TTGKPKLIDV SLKPLNEAKP KIPIIFPLKR
    1151  PQIKPEVSVI NLVQNLVNTK IPEIKNESVD LGSNITDILS STITNILPEI
    1201  TATDVKNYQY EDENVKYLKK TPRQVLNLDG LVPPSGRCIT KAKRVRRIKK
    1251  LSADATTAPE ADGKANSESI TYTFDIPSPE EVQSKRSVVL KFAKARLTEA
    1301  ELSCLKKEIN NVRKRRWREM NSTKNWEYDV KSRLKKRANA FFGEGESETK
    1351  SKWIEERFQE KVSQEKYKDR LETTETQANN TKIVIDDKEI LNILAVNMNN
    1401  LNKARCIEKD IQESFREEKL ASLQPKKKRK KSILH*

external links for Spp41p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Spp41p

1)	Maddock JR, et al. (1994) Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes. Genetics 136(3):833-47