STP1/YDR463W Protein Information Help

Standard Name Stp1p 1
Systematic Name Ydr463wp
Alias Bap1p , Ssy2p 2
ORF Classification Verified
Description Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication (3, 4, 5, 6, 7, 8)
Name Description Species-specific tRNA Processing 1
Experimental Data
Molecules/cell 1310 9
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 519
Molecular Weight (Da) 58,087
Isoelectric Point (pI) 7.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Stp1p (InterPro)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000168E6A | Q00947
MIPS: YDR463W
NCBI: 1711562 | 172769 | 239938845 | 398366619 | 927741 | NP_010751.4
GenBank/EMBL/DDBJ: DAA12298.1 | M88597 | U33050
Amino Acid Sequence (or in FASTA format)
 
       1  MPSTTLLFPQ KHIRAIPGKI YAFFRELVSG VIISKPDLSH HYSCENATKE
      51  EGKDAADEEK TTTSLFPESN NIDRSLNGGC SVIPCSMDVS DLNTPISITL
     101  SPENRIKSEV NAKSLLGSRP EQDTGAPIKM STGVTSSPLS PSGSTPEHST
     151  KVLNNGEEEF ICHYCDATFR IRGYLTRHIK KHAIEKAYHC PFFNSATPPD
     201  LRCHNSGGFS RRDTYKTHLK ARHVLYPKGV KPQDRNKSSG HCAQCGEYFS
     251  TIENFVENHI ESGDCKALPQ GYTKKNEKRS GKLRKIKTSN GHSRFISTSQ
     301  SVVEPKVLFN KDAVEAMTIV ANNSSGNDII SKYGNNKLML NSENFKVDIP
     351  KRKRKYIKKK QQQVSGSTVT TPEVATQNNQ EVAPDEISSA TIFSPFDTHL
     401  LEPVPSSSSE SSAEVMFHGK QMKNFLIDIN SFTNQQQQAQ DNPSFLPLDI
     451  EQSSYDLSED AMSYPIISTQ SNRDCTQYDN TKISQILQSQ LNPEYLSENH
     501  MRETQQYLNF YNDNFGSQF*

external links for Stp1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Stp1p
1) Wang SS and Hopper AK  (1988) Isolation of a yeast gene involved in species-specific pre-tRNA processing. Mol Cell Biol 8(12):5140-9
2) Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
3) Wang SS, et al.  (1992) STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs. Mol Cell Biol 12(6):2633-43
4) Jorgensen MU, et al.  (1997) STP1, a gene involved in pre-tRNA processing in yeast, is important for amino-acid uptake and transcription of the permease gene BAP2. Curr Genet 31(3):241-7
5) de Boer M, et al.  (2000) Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. Nucleic Acids Res 28(4):974-81
6) Andreasson C and Ljungdahl PO  (2002) Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Genes Dev 16(24):3158-72
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Andreasson C, et al.  (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8
9) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41