TOM1/YDR457W Protein Information 
| Standard Name | Tom1p 1 |
|---|---|
| Systematic Name | Ydr457wp |
| ORF Classification | Verified |
| Description | E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase (2, 3, 4, 5, 6, 7, 8) |
| Name Description | Temperature dependent Organization in Mitotic nucleus |
| Experimental Data | |
|---|---|
| Molecules/cell | 358 9 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Tom1p (InterPro) |
| Physical Interactions | There are 34 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000006BC10 | Q03280 MIPS: YDR457W NCBI: 2257705 | 398366613 | 50401412 | 927738 | NP_010745.3 GenBank/EMBL/DDBJ: DAA12291.1 | D63905 | U33050 |
| External Classifications | EC: 6.3.2.- [Acid-Amino-Acid Ligases (Peptide Synthases)] |
external links for Tom1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Candida (CGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | DIP | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Tom1p
| 1) | Utsugi T, et al. (1995) A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta 1263(3):285-8 |
| 2) | Utsugi T, et al. (1999) Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures. Gene 234(2):285-95 |
| 3) | Davey M, et al. (2000) The yeast peptidyl proline isomerases FPR3 and FPR4, in high copy numbers, suppress defects resulting from the absence of the E3 ubiquitin ligase TOM1. Mol Gen Genet 263(3):520-6 |
| 4) | Saleh A, et al. (1998) TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes. J Mol Biol 282(5):933-46 |
| 5) | Duncan K, et al. (2000) A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport. Curr Biol 10(12):687-96 |
| 6) | Singh RK, et al. (2009) Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis. Nat Cell Biol 11(8):925-33 |
| 7) | Kim DH and Koepp DM (2012) Hect E3 ubiquitin ligase Tom1 controls Dia2 degradation during the cell cycle. Mol Biol Cell 23(21):4203-11 |
| 8) | Kim DH, et al. (2012) The Hect domain E3 ligase Tom1 and the F-box protein Dia2 control Cdc6 degradation in G1 phase. J Biol Chem 287(53):44212-20 |
| 9) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
