GPI19/YDR437W Protein Information Help

Standard Name Gpi19p 1
Systematic Name Ydr437wp
ORF Classification Verified
Description Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P (1, 2)
Name Description Glycosyl PhosphatidylInositol anchor biosynthesis 1
Experimental Data
Molecules/cell 752 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 140
Molecular Weight (Da) 16,089
Isoelectric Point (pI) 4

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gpi19p (InterPro)
Transmembrane Domains There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 1 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006BAFD | Q04082
MIPS: YDR437W
NCBI: 398366595 | 74583445 | 927688 | NP_010725.3
GenBank/EMBL/DDBJ: DAA12274.1 | U33007
External Classifications EC: 2.4.1.198 [Phosphatidylinositol N-acetylglucosaminyltransferase]
Amino Acid Sequence (or in FASTA format)
 
       1  MYTKEYYWFS QYMIITSTLV LTIIWSILPS SLGEAAPKQF INTLLDIFPQ
      51  RRWIITLESI MLMGMLCTYI GLLMYNEDTL TPPLDSLSTV TDAGGQLVIE
     101  DDPDVFVKKW AFKETSGIYD LSLMDACQLL YLYDNDHTST *

external links for Gpi19p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gpi19p
1) Newman HA, et al.  (2005) Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Eukaryot Cell 4(11):1801-7
2) Watanabe R, et al.  (2000) Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J 19(16):4402-11
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41