CAD1/YDR423C Protein Information

Standard Name	Cad1p 1
Systematic Name	Ydr423cp
Alias	Yap2p
ORF Classification	Verified
Description	AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7, 8, 9)
Name Description	CADmium resistance 10

Experimental Data
Molecules/cell	623 11

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	409
Molecular Weight (Da)	45,751
Isoelectric Point (pI)	7.03

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cad1p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000126D89 \| P24813 MIPS: YDR423C NCBI: 171145 \| 295590 \| 398366585 \| 416737 \| 471277 \| 545482 \| 927712 \| NP_010711.3 GenBank/EMBL/DDBJ: DAA12263.1 \| L14289 \| M58331 \| S68847 \| U33007 \| X69106

Amino Acid Sequence (or in FASTA format)
1 MGNILRKGQQ IYLAGDMKKQ MLLNKDGTPK RKVGRPGRKR IDSEAKSRRT 51 AQNRAAQRAF RDRKEAKMKS LQERVELLEQ KDAQNKTTTD FLLCSLKSLL 101 SEITKYRAKN SDDERILAFL DDLQEQQKRE NEKGTSTAVS KAAKELPSPN 151 SDENMTVNTS IEVQPHTQEN EKVMWNIGSW NAPSLTNSWD SPPGNRTGAV 201 TIGDESINGS EMPDFSLDLV SNDRQTGLEA LDYDIHNYFP QHSERLTAEK 251 IDTSACQCEI DQKYLPYETE DDTLFPSVLP LAVGSQCNNI CNRKCIGTKP 301 CSNKEIKCDL ITSHLLNQKS LASVLPVAAS HTKTIRTQSE AIEHISSAIS 351 NGKASCYHIL EEISSLPKYS SLDIDDLCSE LIIKAKCTDD CKIVVKARDL 401 QSALVRQLL*

Amino Acid Sequence (or in FASTA format)

       1  MGNILRKGQQ IYLAGDMKKQ MLLNKDGTPK RKVGRPGRKR IDSEAKSRRT
      51  AQNRAAQRAF RDRKEAKMKS LQERVELLEQ KDAQNKTTTD FLLCSLKSLL
     101  SEITKYRAKN SDDERILAFL DDLQEQQKRE NEKGTSTAVS KAAKELPSPN
     151  SDENMTVNTS IEVQPHTQEN EKVMWNIGSW NAPSLTNSWD SPPGNRTGAV
     201  TIGDESINGS EMPDFSLDLV SNDRQTGLEA LDYDIHNYFP QHSERLTAEK
     251  IDTSACQCEI DQKYLPYETE DDTLFPSVLP LAVGSQCNNI CNRKCIGTKP
     301  CSNKEIKCDL ITSHLLNQKS LASVLPVAAS HTKTIRTQSE AIEHISSAIS
     351  NGKASCYHIL EEISSLPKYS SLDIDDLCSE LIIKAKCTDD CKIVVKARDL
     401  QSALVRQLL*

external links for Cad1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cad1p

1)	Januska, A. (1989) Personal Communication, Mortimer Map Edition 10
2)	Lesuisse E and Labbe P (1995) Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae. Microbiology 141 ( Pt 11):2937-43
3)	Vilela C, et al. (1998) The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. Nucleic Acids Res 26(5):1150-9
4)	Hirata D, et al. (1994) Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet 242(3):250-6
5)	Miyahara K, et al. (1996) yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet 29(2):103-5
6)	Fernandes L, et al. (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
7)	Vilela C, et al. (1999) Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J 18(11):3139-52
8)	Cohen BA, et al. (2002) Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Mol Biol Cell 13(5):1608-14
9)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
10)	Wu A, et al. (1993) Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem 268(25):18850-8
11)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41