PDR15/YDR406W Protein Information Help

Standard Name Pdr15p
Systematic Name Ydr406wp
ORF Classification Verified
Description Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Pleiotropic Drug Resistance 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,529
Molecular Weight (Da) 172,254
Isoelectric Point (pI) 7.87

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pdr15p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001314DC | Q04182
MIPS: YDR406W
NCBI: 6093665 | 6320614 | 927337 | NP_010694.1
GenBank/EMBL/DDBJ: DAA12248.1 | U32274
External Classifications TC: 3.A.1.205 [The Pleiotropic Drug Resistance (PDR) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MSSDIRDVEE RNSRSSSSSS SSNSAAQSIG QHPYRGFDSE AAERVHELAR
      51  TLTSQSLLYT ANSNNSSSSN HNAHNADSRS VFSTDMEGVN PVFTNPDTPG
     101  YNPKLDPNSD QFSSTAWVQN MANICTSDPD FYKPYSLGCV WKNLSASGDS
     151  ADVSYQSTFA NIVPKLLTKG LRLLKPSKEE DTFQILKPMD GCLNPGELLV
     201  VLGRPGSGCT TLLKSISSNS HGFKIAKDSI VSYNGLSSSD IRKHYRGEVV
     251  YNAESDIHLP HLTVYQTLFT VARMKTPQNR IKGVDREAYA NHVTEVAMAT
     301  YGLSHTRDTK VGNDLVRGVS GGERKRVSIA EVAICGARFQ CWDNATRGLD
     351  SATALEFIRA LKTQADIGKT AATVAIYQCS QDAYDLFDKV CVLDDGYQLY
     401  FGPAKDAKKY FQDMGYYCPP RQTTADFLTS ITSPTERIIS KEFIEKGTRV
     451  PQTPKDMAEY WLQSESYKNL IKDIDSTLEK NTDEARNIIR DAHHAKQAKR
     501  APPSSPYVVN YGMQVKYLLI RNFWRMKQSA SVTLWQVIGN SVMAFILGSM
     551  FYKVMKKNDT STFYFRGAAM FFAILFNAFS CLLEIFSLYE TRPITEKHRT
     601  YSLYHPSADA FASVLSEMPP KLITAVCFNI IFYFLVDFRR NGGVFFFYFL
     651  INVIATFTLS HLFRCVGSLT KTLQEAMVPA SMLLLAISMY TGFAIPKTKI
     701  LGWSIWIWYI NPLAYLFESL MINEFHDRRF PCAQYIPAGP AYQNITGTQR
     751  VCSAVGAYPG NDYVLGDDFL KESYDYEHKH KWRGFGIGMA YVVFFFFVYL
     801  ILCEYNEGAK QKGEMVVFLR SKIKQLKKEG KLQEKHRPGD IENNAGSSPD
     851  SATTEKKILD DSSEGSDSSS DNAGLGLSKS EAIFHWRDLC YDVPIKGGQR
     901  RILNNVDGWV KPGTLTALMG ASGAGKTTLL DCLAERVTMG VITGNIFVDG
     951  RLRDESFPRS IGYCQQQDLH LKTATVRESL RFSAYLRQPS SVSIEEKNRY
    1001  VEEVIKILEM QQYSDAVVGV AGEGLNVEQR KRLTIGVELA ARPKLLVFLD
    1051  EPTSGLDSQT AWDTCQLMRK LATHGQAILC TIHQPSAILM QQFDRLLFLQ
    1101  KGGQTVYFGD LGEGCKTMID YFESKGAHKC PPDANPAEWM LEVVGAAPGS
    1151  HATQDYNEVW RNSDEYKAVQ EELDWMEKNL PGRSKEPTAE EHKPFAASLY
    1201  YQFKMVTIRL FQQYWRSPDY LWSKFILTIF NQVFIGFTFF KADRSLQGLQ
    1251  NQMLSIFMYT VIFNPILQQY LPSFVQQRDL YEARERPSRT FSWLAFFLSQ
    1301  IIVEIPWNIL AGTIAYCIYY YAVGFYANAS AAGQLHERGA LFWLFSIAFY
    1351  VYIGSMGLLM ISFNEVAETA AHMGTLLFTM ALSFCGVMAT PKVMPRFWIF
    1401  MYRVSPLTYM IDALLALGVA NVDVKCSNYE MVKFTPPSGT TCGDYMASYI
    1451  KLAGTGYLSD PSATDICSFC AVSTTNAFLA TFSSHYYRRW RNYGIFICYI
    1501  AFDYIAATFL YWLSRVPKKN GKISEKPKK*

external links for Pdr15p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Pdr15p
1) Decottignies A, et al.  (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273(20):12612-22
2) Wolfger H, et al.  (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74
3) Hikkel I, et al.  (2003) A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J Biol Chem 278(13):11427-32
4) Wolfger H, et al.  (2004) The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. J Biol Chem 279(12):11593-9
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61