DIT1/YDR403W Protein Information

Standard Name	Dit1p 1
Systematic Name	Ydr403wp
ORF Classification	Verified
Description	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure (1, 2, 3)
Name Description	DITyrosine 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	536
Molecular Weight (Da)	61,390
Isoelectric Point (pI)	6.51

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dit1p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000129421 \| P21623 MIPS: YDR403W NCBI: 1706440 \| 3654 \| 6320611 \| 927334 \| NP_010691.1 \| NM_001180711.1 GenBank/EMBL/DDBJ: DAA12245.1 \| U32274 \| X55712

Amino Acid Sequence (or in FASTA format)
1 MTFTSNLPSS SEQSISPPAS SFSSSTDTLK DIDIPHNGAD LSTYSKFLAL 51 YCRSDKCDDF YSLEEKQNCK FGDQWLDFIN TIHNLDFSES EVSGRVSERI 101 LPASLANKFT NNLGVAIKIS EYTRDDERQI RGCVTTVENE NSFNNWFVYH 151 ILDQSQLSLS EHPIVTKEVK YHELFADFFE KNLKNTIVND QWNFGGRDYF 201 IERSRYFTDR YLRIECILPA FPCKSSNEQK VYGSVPDKGE ELALKRLIKA 251 TQDLVKIYPP GMKIWIVSDG HVFSDCIGVD DDVVSTYTTK LHELYKRVAI 301 PGVDAIGFCG LNDLFFSGAA SKVFDPKWVS DVEVAHYTGT QICPKSDLSR 351 QILMKGCDTD AGRLRKQIAI EGHPRLHLYR GFSRFMMEDL SLLEHFQSYS 401 RKKFKKIISM IAFNMIKRND AYSNLVELIF PHHLRISIHA HTNSGPKFGI 451 KVISNEQCSI VSSLEDLDEP KFEDFLHIPT PWHNCVVKVE DEKEKYFLTK 501 SKVVKEALEK GMYDGVWKDT RFDIGEGGHF VIKKIS*

Amino Acid Sequence (or in FASTA format)

       1  MTFTSNLPSS SEQSISPPAS SFSSSTDTLK DIDIPHNGAD LSTYSKFLAL
      51  YCRSDKCDDF YSLEEKQNCK FGDQWLDFIN TIHNLDFSES EVSGRVSERI
     101  LPASLANKFT NNLGVAIKIS EYTRDDERQI RGCVTTVENE NSFNNWFVYH
     151  ILDQSQLSLS EHPIVTKEVK YHELFADFFE KNLKNTIVND QWNFGGRDYF
     201  IERSRYFTDR YLRIECILPA FPCKSSNEQK VYGSVPDKGE ELALKRLIKA
     251  TQDLVKIYPP GMKIWIVSDG HVFSDCIGVD DDVVSTYTTK LHELYKRVAI
     301  PGVDAIGFCG LNDLFFSGAA SKVFDPKWVS DVEVAHYTGT QICPKSDLSR
     351  QILMKGCDTD AGRLRKQIAI EGHPRLHLYR GFSRFMMEDL SLLEHFQSYS
     401  RKKFKKIISM IAFNMIKRND AYSNLVELIF PHHLRISIHA HTNSGPKFGI
     451  KVISNEQCSI VSSLEDLDEP KFEDFLHIPT PWHNCVVKVE DEKEKYFLTK
     501  SKVVKEALEK GMYDGVWKDT RFDIGEGGHF VIKKIS*

external links for Dit1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Dit1p

1)	Briza P, et al. (1990) Isolation of two developmentally regulated genes involved in spore wall maturation in Saccharomyces cerevisiae. Genes Dev 4(10):1775-89
2)	Friesen H, et al. (1997) An Ssn6-Tup1-dependent negative regulatory element controls sporulation-specific expression of DIT1 and DIT2 in Saccharomyces cerevisiae. Mol Cell Biol 17(1):123-34
3)	Briza P, et al. (1994) The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall. Proc Natl Acad Sci U S A 91(10):4524-8