URH1/YDR400W Protein Information

Standard Name	Urh1p 1
Systematic Name	Ydr400wp
ORF Classification	Verified
Description	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways (1, 2, 3, 4)
Name Description	URidine Hydrolase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	340
Molecular Weight (Da)	37,960
Isoelectric Point (pI)	5.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Urh1p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D4774 \| Q04179 MIPS: YDR400W NCBI: 115502471 \| 12004595 \| 2497466 \| 398366565 \| 927332 \| NP_010688.4 \| NM_001180708.3 GenBank/EMBL/DDBJ: DAA12243.1 \| AF217406 \| U32274
External Classifications	EC: 3.2.2.- [Hydrolysing N-Glycosyl Compounds] EC: 3.2.2.3 [Uridine nucleosidase]

Amino Acid Sequence (or in FASTA format)
1 MTVSKIPIWL DCDPGHDDAI AILLGCFHPA FNLLGISTCF GNAPPENTDY 51 NARSLLTAMG KAQAIPVYKG AQRPWKREPH YAPDIHGISG LDGTSLLPKP 101 TFEARTDKTY IEAIEEAILA NNGEISFVST GALTTLATVF RCKPYLKKSV 151 KYISIMGGGL HGLGNCNPNL SAEFNVWIDP DAANYIFRDP DVKDKCIVVP 201 LNLTHKAIAT YKVNEMIYNE KNNSKLRELF LELFQFFAHT YKDMQGFESG 251 PPIHDPVALM PLLEFYGWDP SSAVGFRYKR MDISCIDDVF NENSGKIIIE 301 KEYPNDSDVG TIIGLDLNIQ YFWDQIFEAL NRADKMSTIG *

Amino Acid Sequence (or in FASTA format)

       1  MTVSKIPIWL DCDPGHDDAI AILLGCFHPA FNLLGISTCF GNAPPENTDY
      51  NARSLLTAMG KAQAIPVYKG AQRPWKREPH YAPDIHGISG LDGTSLLPKP
     101  TFEARTDKTY IEAIEEAILA NNGEISFVST GALTTLATVF RCKPYLKKSV
     151  KYISIMGGGL HGLGNCNPNL SAEFNVWIDP DAANYIFRDP DVKDKCIVVP
     201  LNLTHKAIAT YKVNEMIYNE KNNSKLRELF LELFQFFAHT YKDMQGFESG
     251  PPIHDPVALM PLLEFYGWDP SSAVGFRYKR MDISCIDDVF NENSGKIIIE
     301  KEYPNDSDVG TIIGLDLNIQ YFWDQIFEAL NRADKMSTIG *

external links for Urh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Urh1p

1)	Mitterbauer R, et al. (2002) Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Appl Environ Microbiol 68(3):1336-43
2)	Kurtz JE, et al. (1999) New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet 36(3):130-6
3)	Kurtz JE, et al. (2002) The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Curr Genet 41(3):132-41
4)	Belenky P, et al. (2007) Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129(3):473-84