RPT3/YDR394W Protein Information

Standard Name	Rpt3p 1
Systematic Name	Ydr394wp
Alias	Ynt1p 2 , Yta2p 3
ORF Classification	Verified
Description	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B (4, 5, 6, 7)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	428
Molecular Weight (Da)	47,893
Isoelectric Point (pI)	5.27

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpt3p (InterPro)
Physical Interactions	There are 213 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F98 \| P33298 MIPS: YDR394W NCBI: 152149003 \| 152149005 \| 152149007 \| 158428187 \| 158428189 \| 308153476 \| 313880 \| 398366559 \| 403071971 \| 458389 \| 464861 \| 927327 \| NP_010682.3 GenBank/EMBL/DDBJ: DAA12238.1 \| U06229 \| U32274 \| X73570

Amino Acid Sequence (or in FASTA format)
1 MEELGIVTPV EKAVEEKPAV KSYASLLAQL NGTVNNNSAL SNVNSDIYFK 51 LKKLEKEYEL LTLQEDYIKD EQRHLKRELK RAQEEVKRIQ SVPLVIGQFL 101 EPIDQNTGIV SSTTGMSYVV RILSTLDREL LKPSMSVALH RHSNALVDIL 151 PPDSDSSISV MGENEKPDVT YADVGGLDMQ KQEIREAVEL PLVQADLYEQ 201 IGIDPPRGVL LYGPPGTGKT MLVKAVANST KAAFIRVNGS EFVHKYLGEG 251 PRMVRDVFRL ARENAPSIIF IDEVDSIATK RFDAQTGSDR EVQRILIELL 301 TQMDGFDQST NVKVIMATNR ADTLDPALLR PGRLDRKIEF PSLRDRRERR 351 LIFGTIASKM SLAPEADLDS LIIRNDSLSG AVIAAIMQEA GLRAVRKNRY 401 VILQSDLEEA YATQVKTDNT VDKFDFYK*

Amino Acid Sequence (or in FASTA format)

       1  MEELGIVTPV EKAVEEKPAV KSYASLLAQL NGTVNNNSAL SNVNSDIYFK
      51  LKKLEKEYEL LTLQEDYIKD EQRHLKRELK RAQEEVKRIQ SVPLVIGQFL
     101  EPIDQNTGIV SSTTGMSYVV RILSTLDREL LKPSMSVALH RHSNALVDIL
     151  PPDSDSSISV MGENEKPDVT YADVGGLDMQ KQEIREAVEL PLVQADLYEQ
     201  IGIDPPRGVL LYGPPGTGKT MLVKAVANST KAAFIRVNGS EFVHKYLGEG
     251  PRMVRDVFRL ARENAPSIIF IDEVDSIATK RFDAQTGSDR EVQRILIELL
     301  TQMDGFDQST NVKVIMATNR ADTLDPALLR PGRLDRKIEF PSLRDRRERR
     351  LIFGTIASKM SLAPEADLDS LIIRNDSLSG AVIAAIMQEA GLRAVRKNRY
     401  VILQSDLEEA YATQVKTDNT VDKFDFYK*

external links for Rpt3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rpt3p

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Campbell CL, et al. (1994) Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue. Mol Biol Cell 5(8):899-905
3)	Schnall R, et al. (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
4)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
5)	Glickman MH, et al. (1999) Functional analysis of the proteasome regulatory particle. Mol Biol Rep 26(1-2):21-8
6)	Rubin DM, et al. (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19
7)	Kimura Y, et al. (2003) N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome. Arch Biochem Biophys 409(2):341-8