ARO10/YDR380W Protein Information

Standard Name	Aro10p 1
Systematic Name	Ydr380wp
ORF Classification	Verified
Description	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway (2)
Name Description	AROmatic amino acid requiring 1

Experimental Data
Molecules/cell	6560 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	635
Molecular Weight (Da)	71,384
Isoelectric Point (pI)	6.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aro10p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A539 \| Q06408 MIPS: YDR380W NCBI: 398366545 \| 50400299 \| 849201 \| NP_010668.3 GenBank/EMBL/DDBJ: DAA12223.1 \| U28373
External Classifications	EC: 4.1.1.- [Carboxy-Lyases] EC: 4.1.1.1 [Pyruvate decarboxylase] EC: 4.1.1.72 [Branched-chain-2-oxoacid decarboxylase] EC: 4.1.1.74 [Indolepyruvate decarboxylase]

Amino Acid Sequence (or in FASTA format)
1 MAPVTIEKFV NQEERHLVSN RSATIPFGEY IFKRLLSIDT KSVFGVPGDF 51 NLSLLEYLYS PSVESAGLRW VGTCNELNAA YAADGYSRYS NKIGCLITTY 101 GVGELSALNG IAGSFAENVK VLHIVGVAKS IDSRSSNFSD RNLHHLVPQL 151 HDSNFKGPNH KVYHDMVKDR VACSVAYLED IETACDQVDN VIRDIYKYSK 201 PGYIFVPADF ADMSVTCDNL VNVPRISQQD CIVYPSENQL SDIINKITSW 251 IYSSKTPAIL GDVLTDRYGV SNFLNKLICK TGIWNFSTVM GKSVIDESNP 301 TYMGQYNGKE GLKQVYEHFE LCDLVLHFGV DINEINNGHY TFTYKPNAKI 351 IQFHPNYIRL VDTRQGNEQM FKGINFAPIL KELYKRIDVS KLSLQYDSNV 401 TQYTNETMRL EDPTNGQSSI ITQVHLQKTM PKFLNPGDVV VCETGSFQFS 451 VRDFAFPSQL KYISQGFFLS IGMALPAALG VGIAMQDHSN AHINGGNVKE 501 DYKPRLILFE GDGAAQMTIQ ELSTILKCNI PLEVIIWNNN GYTIERAIMG 551 PTRSYNDVMS WKWTKLFEAF GDFDGKYTNS TLIQCPSKLA LKLEELKNSN 601 KRSGIELLEV KLGELDFPEQ LKCMVEAAAL KRNKK*

Amino Acid Sequence (or in FASTA format)

       1  MAPVTIEKFV NQEERHLVSN RSATIPFGEY IFKRLLSIDT KSVFGVPGDF
      51  NLSLLEYLYS PSVESAGLRW VGTCNELNAA YAADGYSRYS NKIGCLITTY
     101  GVGELSALNG IAGSFAENVK VLHIVGVAKS IDSRSSNFSD RNLHHLVPQL
     151  HDSNFKGPNH KVYHDMVKDR VACSVAYLED IETACDQVDN VIRDIYKYSK
     201  PGYIFVPADF ADMSVTCDNL VNVPRISQQD CIVYPSENQL SDIINKITSW
     251  IYSSKTPAIL GDVLTDRYGV SNFLNKLICK TGIWNFSTVM GKSVIDESNP
     301  TYMGQYNGKE GLKQVYEHFE LCDLVLHFGV DINEINNGHY TFTYKPNAKI
     351  IQFHPNYIRL VDTRQGNEQM FKGINFAPIL KELYKRIDVS KLSLQYDSNV
     401  TQYTNETMRL EDPTNGQSSI ITQVHLQKTM PKFLNPGDVV VCETGSFQFS
     451  VRDFAFPSQL KYISQGFFLS IGMALPAALG VGIAMQDHSN AHINGGNVKE
     501  DYKPRLILFE GDGAAQMTIQ ELSTILKCNI PLEVIIWNNN GYTIERAIMG
     551  PTRSYNDVMS WKWTKLFEAF GDFDGKYTNS TLIQCPSKLA LKLEELKNSN
     601  KRSGIELLEV KLGELDFPEQ LKCMVEAAAL KRNKK*

external links for Aro10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Aro10p

1)	Iraqui I, et al. (1999) Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3360-71
2)	Vuralhan Z, et al. (2003) Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. Appl Environ Microbiol 69(8):4534-41
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41