RGA2/YDR379W Protein Information Help

Standard Name Rga2p 1
Systematic Name Ydr379wp
ORF Classification Verified
Description GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication (1, 2, 3)
Name Description Rho GTPase Activating Protein 1
Experimental Data
Molecules/cell 254 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,009
Molecular Weight (Da) 113,290
Isoelectric Point (pI) 7.81

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rga2p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053122 | Q06407
MIPS: YDR379W
NCBI: 31076883 | 6320587 | 849200 | NP_010667.1 | NM_001180687.1
GenBank/EMBL/DDBJ: AAB64815.1 | DAA12221.1 | U28373
Amino Acid Sequence (or in FASTA format)
       1  MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD
      51  SDFLVLDIGT LICYDCSDKC TNCGDKIDDT AIILPSSNEA YCSNCFRCCR
     101  CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK QLLLENQTKN SSKEDFPIKL
     151  PERSVKRPLS PTRINGKSDV STNNTAISKN LVSSNEDQQL TPQVLVSQER
     201  DESSLNDNND NDNSKDREET SSHARTVSID DILNSTLEHD SNSIEEQSLV
     251  DNEDYINKMG EDVTYRLLKP QRANRDSIVV KDPRIPNSNS NANRFFSIYD
     301  KEETDKDDTD NKENEIIVNT PRNSTDKITS PLNSPMAVQM NEEVEPPHGL
     351  ALTLSEATKE NNKSSQGIQT STSKSMNHVS PITRTDTVEM KTSTSSSTLR
     401  LSDNGSFSRP QTADNLLPHK KVAPSPNKKL SRSFSLKSKN FVHNLKSKTS
     451  EMLDPKHPHH STSIQESDTH SGWGVSSTHT NIRKSKAKKN PVSRGQSDST
     501  IYNTLPQHGN FTVPEFNHKK AQSSLGSISK KQNSNDTATN RRINGSFTSS
     551  SSGHHIAMFR TPPLESGPLF KRPSLSSESA HHRSSSLQTS RSTNALLEDD
     601  STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK KLLQDVENLR
     651  LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK
     701  GSISNASPKP RFWKIFSSAK DHQVGDLESQ QRSPNSSSGG TTNIAQKEIS
     751  SPKLIRVHDE LPSPGKVPLS PSPKRLDYTP DGSHLYGSSL QARCAYEKST
     801  VPIIIRCCID RIEKDDIGLN MEGLYRKSGS QTLVEEIENE FAQNNSLHSD
     851  TLSPKLNALL NQDIHAVASV LKRYLRKLPD PVLSFSIYDA LIDLVRNNQL
     901  IERLPLNNDK FLDSPQKVTI YEMVLKSLLE IFKILPVEHQ EVLKVLAAHI
     951  GKVRRCSERN LMNLHNLSLV FAPSLIHDFD GEKDIVDMKE RNYIVEFILG
    1001  NYRDIFKQA*                                            

external links for Rga2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Rga2p
1) Smith GR, et al.  (2002) GTPase-activating proteins for Cdc42. Eukaryot Cell 1(3):469-80
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Sopko R, et al.  (2007) Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. EMBO J 26(21):4487-500
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41