ARH1/YDR376W Protein Information

Standard Name	Arh1p
Systematic Name	Ydr376wp
ORF Classification	Verified
Description	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability (1, 2, 3)
Name Description	Adrenodoxin Reductase Homolog 2

Experimental Data
Molecules/cell	1600 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	493
Molecular Weight (Da)	56,237
Isoelectric Point (pI)	9.6

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arh1p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012560B \| P48360 MIPS: YDR376W NCBI: 1055300 \| 1351892 \| 258017 \| 398366539 \| 849197 \| 881497 \| NP_010664.3 GenBank/EMBL/DDBJ: DAA12218.1 \| S47189 \| U28038 \| U28373 \| U38689
External Classifications	EC: 1.18.1.6 [Adrenodoxin-NADP(+) reductase]

Amino Acid Sequence (or in FASTA format)
1 MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL 51 PVPFGLSRYG VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI 101 GKEILLKELL DNQDAVILSY GCTGDRKLNI PGELGTKGVF SSREFVNWYN 151 GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV ALDITRVLIS NQIDEIWENT 201 DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW ELEKYGIRGR 251 IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS 301 GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI 351 MTYKVDLLIT SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP 401 HLYASGWIRK GSQGVIASTM QDAFEVGDRV IQDLVVSGAL SLENSIDLSN 451 IKHTTWKDWE RINKKELLRG KKEHKTRSKF LTFEELWNGV EGI*

Amino Acid Sequence (or in FASTA format)

       1  MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL
      51  PVPFGLSRYG VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI
     101  GKEILLKELL DNQDAVILSY GCTGDRKLNI PGELGTKGVF SSREFVNWYN
     151  GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV ALDITRVLIS NQIDEIWENT
     201  DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW ELEKYGIRGR
     251  IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS
     301  GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI
     351  MTYKVDLLIT SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP
     401  HLYASGWIRK GSQGVIASTM QDAFEVGDRV IQDLVVSGAL SLENSIDLSN
     451  IKHTTWKDWE RINKKELLRG KKEHKTRSKF LTFEELWNGV EGI*

external links for Arh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Arh1p

1)	Lacour T, et al. (1998) Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. J Biol Chem 273(37):23984-92
2)	Manzella L, et al. (1998) ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Yeast 14(9):839-46
3)	Li J, et al. (2001) Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis. J Biol Chem 276(2):1503-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41