YPR1/YDR368W Protein Information

Standard Name	Ypr1p
Systematic Name	Ydr368wp
ORF Classification	Verified
Description	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Yeast Putative Reductase 6

Experimental Data
Molecules/cell	14100 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	312
Molecular Weight (Da)	34,755
Isoelectric Point (pI)	7.13

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ypr1p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BE1C \| Q12458 MIPS: YDR368W NCBI: 1103498 \| 2492802 \| 6320576 \| 849189 \| NP_010656.1 GenBank/EMBL/DDBJ: DAA12209.1 \| U28373 \| X80642
External Classifications	EC: 1.1.1.- [Oxidoreductases With NAD+ or NADP+ as acceptor]

Amino Acid Sequence (or in FASTA format)
1 MPATLKNSSA TLKLNTGASI PVLGFGTWRS VDNNGYHSVI AALKAGYRHI 51 DAAAIYLNEE EVGRAIKDSG VPREEIFITT KLWGTEQRDP EAALNKSLKR 101 LGLDYVDLYL MHWPVPLKTD RVTDGNVLCI PTLEDGTVDI DTKEWNFIKT 151 WELMQELPKT GKTKAVGVSN FSINNIKELL ESPNNKVVPA TNQIEIHPLL 201 PQDELIAFCK EKGIVVEAYS PFGSANAPLL KEQAIIDMAK KHGVEPAQLI 251 ISWSIQRGYV VLAKSVNPER IVSNFKIFTL PEDDFKTISN LSKVHGTKRV 301 VDMKWGSFPI FQ*

Amino Acid Sequence (or in FASTA format)

       1  MPATLKNSSA TLKLNTGASI PVLGFGTWRS VDNNGYHSVI AALKAGYRHI
      51  DAAAIYLNEE EVGRAIKDSG VPREEIFITT KLWGTEQRDP EAALNKSLKR
     101  LGLDYVDLYL MHWPVPLKTD RVTDGNVLCI PTLEDGTVDI DTKEWNFIKT
     151  WELMQELPKT GKTKAVGVSN FSINNIKELL ESPNNKVVPA TNQIEIHPLL
     201  PQDELIAFCK EKGIVVEAYS PFGSANAPLL KEQAIIDMAK KHGVEPAQLI
     251  ISWSIQRGYV VLAKSVNPER IVSNFKIFTL PEDDFKTISN LSKVHGTKRV
     301  VDMKWGSFPI FQ*

external links for Ypr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ypr1p

1)	Petrash JM, et al. (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132(1-3):673-83
2)	Ford G and Ellis EM (2002) Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase. Yeast 19(12):1087-96
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Chang Q, et al. (2007) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta 1773(3):321-9
5)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6)	Nakamura K, et al. (1997) Amino acid sequence and characterization of aldo-keto reductase from bakers' yeast. Biosci Biotechnol Biochem 61(2):375-7
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41