CDC40/YDR364C Protein Information Help

Standard Name Cdc40p 1, 2
Systematic Name Ydr364cp
Alias Prp17p 3 , Slt15p 4 , Slu4p 5
ORF Classification Verified
Description Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats (6)
Name Description Cell Division Cycle 1
Experimental Data
Molecules/cell 1630 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 455
Molecular Weight (Da) 52,047
Isoelectric Point (pI) 7.2

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cdc40p (InterPro)
Physical Interactions There are 43 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531F5 | P40968
MIPS: YDR364C
NCBI: 3041659 | 398366525 | 575457 | 849185 | NP_010652.3 | NM_001180672.3
GenBank/EMBL/DDBJ: AAA86875.1 | AAB64800.1 | DAA12203.1 | U17018 | U28373
Amino Acid Sequence (or in FASTA format)
       1  MGLVDGYDTS SDSDLNFDEG KSVHEKKNGN LHEDTSYEPS SNNIHKRKSH
      51  FTKSELKRRR KTRKGDGPWG SWSSSDDETS QASETQKEDQ DIFVHALAED
     101  NLDSEQIEVE EVSHFYGKSE KDYQGRGYLY PPNDVDVDLR EERISFRCYL
     151  PKKVIRNYPG HPEGTTALKF LPKTGHLILS GGNDHTIKIW DFYHDYECLR
     201  DFQGHNKPIK ALRFTEDCQS FLSSSFDRSV KIWDTETGKV KTRLHLNSTP
     251  ADVESRPTNP HEFIVGLSNS KILHYDDRVS ENQGLVQTYD HHLSSILALK
     301  YFPDGSKFIS SSEDKTVRIW ENQINVPIKQ ISDTAQHSMP FLNVHPSQNY
     351  FCAQSMDNRI YSFSLKPKYK RHPKKIFKGH SSAGYGISLA FSGDGRYICS
     401  GDSKSRLFTW DWNTSRLLNN IKIPGNKPIT QVDWHPQETS KVICSGAAGK
     451  IYVCD*                                                

external links for Cdc40p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) CYC2008 (complexes) MIPS YeastRC Public Image Repository
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Cdc40p
1) Kassir Y and Simchen G  (1978) Meiotic recombination and DNA synthesis in a new cell cycle mutant of Saccharomyces cerevisiae. Genetics 90(1):49-68
2) Kassir, Y., et al.  (1985) Personal Communication, Mortimer Map Edition 9
3) Vijayraghavan U, et al.  (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
4) Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
5) Frank D, et al.  (1992) Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 12(11):5197-205
6) Lindsey-Boltz LA, et al.  (2000) The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. RNA 6(9):1289-305
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41