ESC2/YDR363W Protein Information

Standard Name	Esc2p 1
Systematic Name	Ydr363wp
ORF Classification	Verified
Description	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member (1, 2, 3, 4, 5)
Name Description	Establishment of Silent Chromatin 1

Experimental Data
Molecules/cell	1890 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	456
Molecular Weight (Da)	52,541
Isoelectric Point (pI)	4.79

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Esc2p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006AA97 \| Q06340 MIPS: YDR363W NCBI: 6320570 \| 74583556 \| 849171 \| NP_010650.1 \| NM_001180671.1 GenBank/EMBL/DDBJ: DAA12201.1 \| U28372

Amino Acid Sequence (or in FASTA format)
1 MTGDSRSISE PSINLDPDNT SFSDENSDDF FMDNSYDIDE IDHSDESNRQ 51 SVIVDSKVTV PPSKHSTLTL SDSEDSDAKE QHQSLSRSSS KNVNIEDITE 101 PKPDKPSGRT RGRSVMKESV VEINSSESDL DEDKNFPRSR SRSRSSIRSI 151 SPAGKYKRQK SSLLYTYDEN DDFFKELAKE AKKSTTISKE STPDQRKRVY 201 NIKFLSKLEG TINKAVQVKV LGKYEFSKIL PAALDGLMKS YKIPKVMKDI 251 YKVENVTLYW NNAKLLTFMT CNSLHIPQDF ENEVSDIDVT IVSKEYEKNF 301 EATLESKLKE EEAALLIKER QEMERKLEKK RNEQEESEYR EFESELKNVE 351 ETQEIKENDT VMNTKLLQEG GSLSGNSSSM EEVMRIALMG QDNKKIYVHV 401 RRSTPFSKIA EYYRIQKQLP QKTRVKLLFD HDELDMNECI ADQDMEDEDM 451 VDVIID*

Amino Acid Sequence (or in FASTA format)

       1  MTGDSRSISE PSINLDPDNT SFSDENSDDF FMDNSYDIDE IDHSDESNRQ
      51  SVIVDSKVTV PPSKHSTLTL SDSEDSDAKE QHQSLSRSSS KNVNIEDITE
     101  PKPDKPSGRT RGRSVMKESV VEINSSESDL DEDKNFPRSR SRSRSSIRSI
     151  SPAGKYKRQK SSLLYTYDEN DDFFKELAKE AKKSTTISKE STPDQRKRVY
     201  NIKFLSKLEG TINKAVQVKV LGKYEFSKIL PAALDGLMKS YKIPKVMKDI
     251  YKVENVTLYW NNAKLLTFMT CNSLHIPQDF ENEVSDIDVT IVSKEYEKNF
     301  EATLESKLKE EEAALLIKER QEMERKLEKK RNEQEESEYR EFESELKNVE
     351  ETQEIKENDT VMNTKLLQEG GSLSGNSSSM EEVMRIALMG QDNKKIYVHV
     401  RRSTPFSKIA EYYRIQKQLP QKTRVKLLFD HDELDMNECI ADQDMEDEDM
     451  VDVIID*

external links for Esc2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Esc2p

1)	Dhillon N and Kamakaka RT (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80
2)	Novatchkova M, et al. (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6():22
3)	Ohya T, et al. (2008) A SUMO-Like Domain Protein, Esc2, Is Required for Genome Integrity and Sister Chromatid Cohesion in Saccharomyces cerevisiae. Genetics 180(1):41-50
4)	Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94
5)	Choi K, et al. (2010) The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2306-14
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41