TFC6/YDR362C Protein Information

Standard Name	Tfc6p 1
Systematic Name	Ydr362cp
ORF Classification	Verified
Description	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 (1, 2)
Name Description	Transcription Factor C 1
Gene Product	tau 91 3

Experimental Data
Molecules/cell	1130 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	672
Molecular Weight (Da)	74,708
Isoelectric Point (pI)	6.57

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tfc6p (InterPro)
Physical Interactions	There are 36 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E28 \| Q06339 MIPS: YDR362C NCBI: 118138573 \| 118138575 \| 6320569 \| 74583555 \| 849183 \| NP_010649.1 \| NM_001180670.1 GenBank/EMBL/DDBJ: DAA12200.1 \| U28372

Amino Acid Sequence (or in FASTA format)
1 MAVIPAKKRG RPRKSVVAEV PYDSLASPVS ENSGSKRPRR NASKKAVANF 51 AQLVHAGRDD VINTTQVNNV DDTDDDDFVL NDEGDGEESD NVEIEFENEL 101 ESTKNEVADL NSSGSGASVR PSGRRNTVQK LRLKKNSTKN MKSSSPGSSL 151 GQKGRPIRLL KDLSSARDKI ERIYGLNKEK LLLLAKVKEG FETSVFDFPF 201 KNIQPDSPYF VCLDPPCKKE SAYNKVIGDK NRTVYHEINK TEFENMIKLR 251 TKRLKLLIGE VDAEVSTGDK IEFPVLANGK RRGFIYNVGG LVTDIAWLNI 301 EENTDIGKDI QYLAVAVSQY MDEPLNEHLE MFDKEKHSSC IQIFKMNTST 351 LHCVKVQTIV HSFGEVWDLK WHEGCHAPHL VGCLSFVSQE GTINFLEIID 401 NATDVHVFKM CEKPSLTLSL ADSLITTFDF LSPTTVVCGF KNGFVAEFDL 451 TDPEVPSFYD QVHDSYILSV STAYSDFEDT VVSTVAVDGY FYIFNPKDIA 501 TTKTTVSRFR GSNLVPVVYC PQIYSYIYSD GASSLRAVPS RAAFAVHPLV 551 SRETTITAIG VSRLHPMVLA GSADGSLIIT NAARRLLHGI KNSSATQKSL 601 RLWKWDYSIK DDKYRIDSSY EVYPLTVNDV SKAKIDAHGI NITCTKWNET 651 SAGGKCYAFS NSAGLLTLEY LS*

Amino Acid Sequence (or in FASTA format)

       1  MAVIPAKKRG RPRKSVVAEV PYDSLASPVS ENSGSKRPRR NASKKAVANF
      51  AQLVHAGRDD VINTTQVNNV DDTDDDDFVL NDEGDGEESD NVEIEFENEL
     101  ESTKNEVADL NSSGSGASVR PSGRRNTVQK LRLKKNSTKN MKSSSPGSSL
     151  GQKGRPIRLL KDLSSARDKI ERIYGLNKEK LLLLAKVKEG FETSVFDFPF
     201  KNIQPDSPYF VCLDPPCKKE SAYNKVIGDK NRTVYHEINK TEFENMIKLR
     251  TKRLKLLIGE VDAEVSTGDK IEFPVLANGK RRGFIYNVGG LVTDIAWLNI
     301  EENTDIGKDI QYLAVAVSQY MDEPLNEHLE MFDKEKHSSC IQIFKMNTST
     351  LHCVKVQTIV HSFGEVWDLK WHEGCHAPHL VGCLSFVSQE GTINFLEIID
     401  NATDVHVFKM CEKPSLTLSL ADSLITTFDF LSPTTVVCGF KNGFVAEFDL
     451  TDPEVPSFYD QVHDSYILSV STAYSDFEDT VVSTVAVDGY FYIFNPKDIA
     501  TTKTTVSRFR GSNLVPVVYC PQIYSYIYSD GASSLRAVPS RAAFAVHPLV
     551  SRETTITAIG VSRLHPMVLA GSADGSLIIT NAARRLLHGI KNSSATQKSL
     601  RLWKWDYSIK DDKYRIDSSY EVYPLTVNDV SKAKIDAHGI NITCTKWNET
     651  SAGGKCYAFS NSAGLLTLEY LS*

external links for Tfc6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tfc6p

1)	Arrebola R, et al. (1998) Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Mol Cell Biol 18(1):1-9
2)	Geiduschek EP and Kassavetis GA (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26
3)	Jourdain S, et al. (2003) The tau95 subunit of yeast TFIIIC influences upstream and downstream functions of TFIIIC.DNA complexes. J Biol Chem 278(12):10450-7
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41